Wanifuchi H, Kagawa M, Takeshita M, Izawa M, Maruyama S, Kitamura K
No Shinkei Geka. 1986 Jan;14(1):31-5.
The association of autoimmune antibody and HLA antibody has been documented concerning the pathogenesis of moyamoya disease. In this paper, we study the autoimmune antibody in moyamoya disease and discuss its relationship with the pathogenesis. Autoimmune antibody was evaluated in 13 cases of moyamoya disease. The age distribution of the patients ranged from 13 to 55, with an average of 37 years. Eight were females, 5 males. Autoantibody was studied with native DNA (double strand DNA) and ANA (antinuclear antibody). Antibody was noted in 3 cases (23%) in native DNA study, and 2 cases (15%) in ANA study. Significantly high incidence was recognized compared with normal control (4%). In relation to the clinical features, such as initial symptoms, time of onset, neurological findings, no significant correlation was recognized. This study suggests that immunological factors might play a partial role in the pathogenesis of moyamoya disease.
自身免疫抗体与HLA抗体的关联已被记录在烟雾病的发病机制中。在本文中，我们研究了烟雾病中的自身免疫抗体，并讨论其与发病机制的关系。对13例烟雾病患者的自身免疫抗体进行了评估。患者的年龄分布为13至55岁，平均37岁。女性8例，男性5例。采用天然DNA（双链DNA）和抗核抗体（ANA）研究自身抗体。在天然DNA研究中，3例（23%）发现抗体，在ANA研究中，2例（15%）发现抗体。与正常对照（4%）相比，发病率显著升高。关于初始症状、发病时间、神经学表现等临床特征，未发现显著相关性。本研究表明，免疫因素可能在烟雾病的发病机制中起部分作用。
