从矿区采集的 MST7-3 化学成分的抗菌活性。
Antibacterial activities of the chemical constituents of MST7-3 collected from coal area.
机构信息
State Key Laboratory of Functions and Applications of Medicinal Plants & School of Pharmacy, Guizhou Medical University, Guiyang, Guizhou, China.
Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Ministry of Education, Guiyang, Guizhou, China.
出版信息
Nat Prod Res. 2022 Sep;36(18):4651-4660. doi: 10.1080/14786419.2021.2010075. Epub 2021 Dec 2.
Two fusidane-type active compounds ( and ) and five new ones (), along with other nine known compounds () were isolated from the metabolites of MST7-3. Their structures were elucidated on the basis of spectroscopic analysis. The absolute configurations of compounds and were established by Mosher's method and optical rotation. Compounds and showed significant antibacterial activities against with MIC values of 4 μg/mL and 16 μg/mL, respectively.
从 MST7-3 的代谢产物中分离得到两种 fusidane 型活性化合物（和）和五种新化合物（），以及其他九种已知化合物（）。基于光谱分析确定了它们的结构。通过 Mosher 法和旋光确定了化合物和的绝对构型。化合物和对表现出显著的抗菌活性，MIC 值分别为 4μg/mL 和 16μg/mL。
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