Faculty of Science, Department of Chemistry, University of Dschang, Dschang, Cameroon.
Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Bielefeld, Germany.
Nat Prod Res. 2022 Sep;36(18):4661-4671. doi: 10.1080/14786419.2021.2010195. Epub 2021 Dec 2.
Chemical investigation of P. Beauv fruits led to the isolation of a new -tocotrienol, 3-hydroxy-δ-tocotrienol () together with eight known compounds (-). Compound ( was allylated () and prenylated ( and ) to give three new semi-synthesized derivatives which were fully characterized as: 6--allyl-3-hydroxy-δ-tocotrienol (), 6--prenyl-3-hydroxy-δ-tocotrienol () and 6-,5-C-diprenyl-3-hydroxy-δ-tocotrienol (). The structures of compounds were established using comprehensive spectroscopic analysis including UV, MS, 1 D NMR, 2 D NMR and by comparison with the corresponding literature data. Compound () and its semi-synthetic derivatives () were tested for their antioxydant activity using DPPH radical scavenging assay and also for their cytotoxicity using human cervix carcinoma KB-3-1 cell lines. The results showed that compound ( exhibited antioxidant activity with an IC value of 0.25 M compared to the reference control trolox (26 M); and good cytotoxic activity with IC values of 97 M compared to the reference (+)-griseofulvin (IC between17-21 M).
佩兰果实的化学成分研究分离得到一种新的 -生育三烯酚，3-羟基-δ-生育三烯酚（），以及 8 种已知化合物（-）。化合物（）经烯丙基化（）和法尼基化（和）得到三种新的半合成衍生物，它们被完全表征为：6--烯丙基-3-羟基-δ-生育三烯酚（），6--法尼基-3-羟基-δ-生育三烯酚（）和 6,5-C-二法尼基-3-羟基-δ-生育三烯酚（）。通过综合光谱分析，包括 UV、MS、1D NMR、2D NMR 以及与相应文献数据的比较，确定了化合物的结构。对化合物（）及其半合成衍生物（）进行了 DPPH 自由基清除试验的抗氧化活性测试，以及对人宫颈癌细胞株 KB-3-1 的细胞毒性测试。结果表明，化合物（）表现出抗氧化活性，IC 值为 0.25 M，与参考对照 Trolox（26 M）相比；具有良好的细胞毒性活性，IC 值为 97 M，与参考 (+)-灰黄霉素（IC 值在 17-21 M 之间）相比。
