Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé P.O. Box 812, Cameroon.
Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé P.O. Box 47, Cameroon.
Molecules. 2023 Mar 8;28(6):2473. doi: 10.3390/molecules28062473.
The chemical investigation of the -hexane fraction from the methanol extract of the stem bark of Linn f., which displayed good in vitro activity against NR-48822 promastigotes (IC 43.11 µg/mL), led to the isolation of three previously unreported polyprenylated benzophenones, guttiferone U (), V ()/W (), and a new tocotrienol derivative named globuliferanol (), along with 11 known compounds (-). Their structures were elucidated based on their NMR and MS data. Some isolated compounds were assessed for both their antileishmanial and cytotoxic activities against and Vero cells, respectively. Guttiferone K () exhibited the best potency (IC 3.30 μg/mL), but with low selectivity to Vero cells. The -hexane fraction and some compounds were also assessed in vitro for their antibacterial activity against seven bacterial strains. All the samples exhibited moderate to potent antibacterial activity (MICs ≤ 15.6 µg/mL) against at least one of the tested strains.
从 Linn f. 的茎皮甲醇提取物的 -己烷部分的化学研究，该部分对 NR-48822 前鞭毛体表现出良好的体外活性（IC 43.11 µg/mL），分离得到了三种以前未报道的多聚异戊二烯基苯并二酮，分别是 guttiferone U ()、V ()/W ()和一种新的生育三烯醇衍生物命名为 globuliferanol ()，以及 11 种已知化合物 (-)。根据它们的 NMR 和 MS 数据阐明了它们的结构。一些分离得到的化合物分别针对抗利什曼原虫和对 和 Vero 细胞的细胞毒性进行了评估。Guttiferone K ()表现出最好的活性（IC 3.30 μg/mL），但对 Vero 细胞的选择性较低。-己烷部分和一些化合物也针对 7 种细菌菌株的体外抗菌活性进行了评估。所有样品对至少一种测试菌株均表现出中度至强的抗菌活性（MICs ≤ 15.6 µg/mL）。
