Medicine Service, Birmingham VA Medical Center, Birmingham, AL, USA.
Department of Medicine at School of Medicine, Division of Epidemiology at School of Public Health, University of Alabama, Faculty Office Tower 805B, 510 20th Street S, Birmingham, AL, 35294, USA.
Arthritis Res Ther. 2021 Dec 1;23(1):291. doi: 10.1186/s13075-021-02676-8.
To examine patient experience, views, and opinions regarding the ineffectiveness of the current knee osteoarthritis (OA) treatments.
Nominal groups were conducted with consecutive clinic patients with knee OA, oversampling African Americans. Patients discussed and rank-ordered their concerns.
Fourteen nominal groups with 48 knee OA patients were conducted with a mean age of 60.6 years (standard deviation, 9.8) and a knee OA duration of 7.8 years (sd, 5.4); 25% were men, and 54% were African American. The most frequently cited highly ranked concerns for the ineffectiveness of current knee OA treatments were as follows: (1) medication-related-(A) side effects (3 groups; 4% vote), (B) limited efficacy (5 groups; 11% vote), (C) medication not targeting underlying disease (7 groups; 16% vote), (D) lack of personalized medication use (3 groups; 4% vote), (E) temporary benefit (3 groups; 6% vote), and (F) fear of addiction/natural treatment preference (2 groups; 3% vote); (2) exercise/physical therapy-related-(G) exacerbation of joint pain (1 group; 3% vote), (H) difficulty in doing exercises (2 groups; 2% vote), (I) lack of motivation (8 groups; 12% vote), (J) technical challenges/lack of personalized exercise regimens (1 group; 1% vote), and (K) cost (2 groups; 3% vote); and (3) weight loss-related-(L) difficulty in achieving weight loss (4 groups; 6% vote) and (M) motivation (1 group; 1% vote).
A representative sample of participants with knee OA identified several barriers to the effectiveness of current knee OA treatments. This new knowledge provides insights for making the current treatment options potentially more usable and/or more effective.
探讨患者对当前膝骨关节炎（OA）治疗效果不佳的体验、看法和意见。
对连续就诊的膝 OA 患者进行名义小组讨论，对非裔美国人进行过采样。患者讨论并对其关注问题进行排序。
共进行了 14 个名义小组，每组 48 例膝 OA 患者，平均年龄为 60.6 岁（标准差 9.8），膝 OA 病程为 7.8 年（标准差 5.4）；25%为男性，54%为非裔美国人。当前膝 OA 治疗效果不佳的最常被引用的高度关注问题如下：（1）药物相关-（A）副作用（3 组；4%投票），（B）疗效有限（5 组；11%投票），（C）药物未针对潜在疾病（7 组；16%投票），（D）缺乏个性化药物使用（3 组；4%投票），（E）暂时获益（3 组；6%投票），（F）担心成瘾/自然治疗偏好（2 组；3%投票）；（2）运动/物理治疗相关-（G）关节疼痛加剧（1 组；3%投票），（H）运动困难（2 组；2%投票），（I）缺乏动力（8 组；12%投票），（J）技术挑战/缺乏个性化运动方案（1 组；1%投票），（K）费用（2 组；3%投票）；（3）减肥相关-（L）减肥困难（4 组；6%投票）和（M）动力（1 组；1%投票）。
有代表性的膝 OA 患者样本确定了当前膝 OA 治疗效果不佳的几个障碍。这些新知识为提高当前治疗方案的可用性和/或有效性提供了新的见解。
