Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University.
Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University.
Biol Pharm Bull. 2021;44(12):1886-1890. doi: 10.1248/bpb.b21-00517.
A lactic acid bacterial strain, Lactobacillus plantarum SN35N, which has been isolated from the pear, secretes negatively charged acidic exopolysaccharide (EPS) to outside cells. We have previously found that the SN35N-derived acidic EPS inhibits the catalytic activity of hyaluronidase (EC 3.2.1.35) promoting inflammation. The aim of this study is to find other health benefits of EPS. EPS has been found to exhibit an inhibitory effect against the influenza virus (Alphainfluenzavirus Influenza A virus) and feline calicivirus (Vesivirus Feline calicivirus), which is recognized as a model of norovirus. Although more studies on the structure-function relationship of EPSs are needed, SN35N-derived EPS is a promising lead for developing not only anti-inflammatory agents, but also antiviral substances.
从梨中分离出的一株乳酸菌植物乳杆菌 SN35N 会向细胞外分泌带负电荷的酸性胞外多糖 (EPS)。我们之前发现，SN35N 衍生的酸性 EPS 可抑制炎症促进剂透明质酸酶 (EC 3.2.1.35) 的催化活性。本研究旨在寻找 EPS 的其他健康益处。EPS 已被发现对流感病毒 (甲型流感病毒) 和猫杯状病毒 (杯状病毒猫杯状病毒) 具有抑制作用，后者被认为是诺如病毒的模型。尽管需要对 EPS 的结构-功能关系进行更多研究，但 SN35N 衍生的 EPS 不仅有望开发出抗炎剂，还有望开发出抗病毒物质。
