Laboratory of Organic Chemistry, Gifu Pharmaceutical University.
Chem Pharm Bull (Tokyo). 2021;69(12):1200-1205. doi: 10.1248/cpb.c21-00749.
A protocol for the ruthenium-on-carbon (Ru/C)-catalyzed solvent-free oxidation of alcohols, which proceeds efficiently under solid-solid (liquid)-gas conditions, was developed. Various primary and secondary alcohols were transformed to corresponding aldehydes and ketones in moderate to excellent isolated yields by simply stirring in the presence of 10% Ru/C under air or oxygen conditions. The solvent-free oxidation reactions proceeded efficiently regardless of the solid or liquid state of the substrates and reagents and could be applied to gram-scale synthesis without loss of the reaction efficiency. Furthermore, the catalytic activity of Ru/C was maintained after five reuse cycles.
开发了一种用于钌/碳 (Ru/C) 催化的醇无溶剂氧化的方案，该方案在固-固（液）-气条件下高效进行。各种伯醇和仲醇在空气中或氧气存在下，只需在 10% Ru/C 的存在下搅拌，即可以中等至优异的收率转化为相应的醛和酮。无溶剂氧化反应无论底物和试剂是固态还是液态，都能高效进行，并且可以应用于克级规模的合成而不损失反应效率。此外，Ru/C 的催化活性在经过五次重复使用循环后仍能保持。
