Madsbad S, Buschard K, Siemssen O, Røpke C
Acta Chir Scand. 1986 Feb;152:81-4.
In seven patients undergoing elective cholecystectomy or vagotomy, helper and suppressor/cytotoxic T-cells were quantified by use of monoclonal antibodies (OKT) preoperatively and on postoperative days 2 and 7. The total number and percentage distribution of T-cells (OKT 3) did not change significantly in the study period and the total number of helper T-cells (OKT 4) was similar in the three tests, but the number of suppressor/cytotoxic T-cells (OKT 8) on postoperative days 2 and 7 showed significant rise from the preoperative value. Consequently, significant decrease in OKT 4/8 ratio was found 2 days (1.47 +/- 0.23) and 7 days (1.80 +/- 0.28) postoperatively, as compared with the preoperative ratio (2.85 +/- 0.44). Since reduced ratio of OKT 4/8 has been shown in disorders associated with diminished immunocompetence, our findings may be related to the increased susceptibility to bacterial infections seen in post-surgery patients.
在7例行择期胆囊切除术或迷走神经切断术的患者中，术前及术后第2天和第7天使用单克隆抗体（OKT）对辅助性T细胞和抑制/细胞毒性T细胞进行定量分析。在研究期间，T细胞（OKT 3）的总数和百分比分布没有显著变化，三次检测中辅助性T细胞（OKT 4）的总数相似，但术后第2天和第7天抑制/细胞毒性T细胞（OKT 8）的数量较术前值显著增加。因此，术后第2天（1.47±0.23）和第7天（1.80±0.28）的OKT 4/8比值与术前比值（2.85±0.44）相比显著降低。由于在免疫能力下降相关的疾病中已显示OKT 4/8比值降低，我们的研究结果可能与术后患者细菌感染易感性增加有关。
