The prediction of gross domestic product (GDP) is a research hotspot, and its importance is self-evident. Its complex internal change mechanism also increases the difficulty of analyzing GDP data. The genetic algorithm (GA) is applied to the parameter design of the radial basis function neural network (RBFNN) based on genetic algorithm optimization (RBFNN-GA). An economic zone GDP image prediction model is proposed, which realizes the optimal design of the center vector, the base width vector of the RBFNN node function, and the weight between the hidden layer and output layer. Based on the GDP data over the years, this paper uses the RBFNN-GA prediction model to analyze and predict the GDP image and compares the image prediction results. The results show that the genetic algorithm is used to optimize RBFNN, which gives full play to the advantages of the two algorithms. The relative error of the RBFNN-GA prediction model is only 3.52%. Compared with the prediction results, the prediction accuracy is significantly higher than the ARIMA time series model and GM (1,1) model.