绿茶提取物和高加索柿果实组成物的抗突变作用。

Antimutagenic Effects of the Composition from Green Tea Leaves Extracts and Caucasian Persimmon Fruits.

机构信息

Lankaran State University, Lankaran, Azerbaijan.

Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.

出版信息

Bull Exp Biol Med. 2021 Dec;172(2):143-145. doi: 10.1007/s10517-021-05351-9. Epub 2021 Dec 2.

DOI:10.1007/s10517-021-05351-9

PMID:34853971

Abstract

On a culture of human peripheral blood lymphocytes, antimutagenic activity of a composition from extracts of green tea leaves and Caucasian persimmon fruits was established with a modification of the mutation process induced by chemical compounds producing an alkylating effect (nitrosomethylurea and sodium fluoride). A concentration dependence of the antimutagenic efficiency of the studied phytocomposite was shown. The highest antimutagenic efficiency was observed when a combination of green tea extract at a concentration of 0.01 μg/ml and persimmon fruit extract at a concentration of 0.001 μg/ml were used. Moreover, this combination was most effective against mutations induced by both nitrosomethylurea and sodium fluoride: the antimutagen efficiency factor was 0.53 and 0.55, respectively.

摘要

在培养人体外周血淋巴细胞的过程中，通过修改由具有烷化作用的化合物（亚硝甲基脲和氟化钠）诱导的突变过程，证实了绿茶和高加索柿子果实提取物的组合物具有抗突变活性。研究表明，该植物混合物的抗突变效率与浓度有关。当绿茶提取物的浓度为 0.01μg/ml 和柿子果实提取物的浓度为 0.001μg/ml 时，观察到最高的抗突变效率。此外，该组合对亚硝甲基脲和氟化钠诱导的突变最为有效：抗突变效率因子分别为 0.53 和 0.55。