Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences - Research Institute of Medical Problems of the North, Krasnoyarsk, Russia.
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
Bull Exp Biol Med. 2021 Dec;172(2):187-190. doi: 10.1007/s10517-021-05360-8. Epub 2021 Dec 2.
We studied the association of expression of CDX2, CK20, CK7 proteins with familial predisposition to stomach cancer in schoolchildren with gastritis and its activity. Gastroscopy with biopsy of the gastric mucosa was performed in 89 schoolchildren aged 7-17 years with gastrointestinal complaints. The morphological study included the diagnosis of gastritis (Sydney classification) and the presence of Helicobacter pylori. The expression of CDX2, CK20, and CK7 was evaluated immunohistochemically. In children with familial predisposition to stomach cancer, the expression of CK20 in the stomach body was significantly increased (p=0.0225). In addition, the expression of CK20 (p=0.0979) and CDX2 (p=0.0849) tended to insrease in the antral compartment. No significant differences in the expression of CK7 in the gastric antrum and body were found. Some features of the expression of CDX2, CK20, and CK7 proteins in children with family predisposition to stomach cancer were revealed.
我们研究了 CDX2、CK20、CK7 蛋白的表达与儿童胃炎及其活动的胃癌家族易感性的关系。对 89 名有胃肠道症状的 7-17 岁儿童进行了胃镜检查和胃黏膜活检。形态学研究包括胃炎的诊断（悉尼分类）和幽门螺杆菌的存在。采用免疫组织化学法评价 CDX2、CK20 和 CK7 的表达。在有胃癌家族易感性的儿童中，胃体 CK20 的表达显著增加（p=0.0225）。此外，CK20（p=0.0979）和 CDX2（p=0.0849）的表达在胃窦部也有增加的趋势。胃窦和胃体 CK7 的表达无显著差异。揭示了有胃癌家族易感性的儿童中 CDX2、CK20 和 CK7 蛋白表达的一些特征。
