Mezzomo Natália Fernandes, da Silva Schmitz Izaviani, de Lima Valtieri Bortoluzzi, Dorneles Gilson Pires, Schaffer Larissa Finger, Boeck Carina Rodrigues, Romao Pedro Roosevelt Torres, Peroza Luis Ricardo
Mestrado em Ciências da Saúde e da Vida, Universidade Franciscana (UFN), Santa Maria, RS, Brazil.
Curso de Biomedicina, Universidade Franciscana (UFN), Santa Maria, RS, Brazil.
Mol Biol Rep. 2022 Mar;49(3):1917-1923. doi: 10.1007/s11033-021-07003-7. Epub 2021 Dec 1.
Schizophrenia is a mental illness and its pharmacological treatment consists in the administration of antipsychotics like haloperidol. However, haloperidol often causes extrapyramidal motor disorders such as tardive dyskinesia (TD). So far, there is no effective treatment against TD and alternatives for it have been sought. Isoflafones have been studied as neuroprotector and inhibitor of monoamine oxidase enzyme. Thus, the objective is to evaluate the possible protective effect of isoflavones against the induction of involuntary movements induced by haloperidol in an animal model.
Male Wistar rats were treated with haloperidol (1 mg/kg/day) and/or isoflavones (80 mg/kg) for 28 days. Rats were submitted to behavioral evaluation to quantify vacuous chewing movements (VCM) and locomotor activity. In addition, the levels of pro-inflammatory cytokines were measured in the striatum. Haloperidol treatment reduced the locomotor activity and increased the number of VCM in rats. Co-treatment with isoflavones was able to reverse hypolocomotion and reduce the number of VCM. Besides, haloperidol caused significant increase in the proinflammatory cytokines (interleukin-1β:IL-1β, tumor necrosis factor-α: TNF-α and IL-6 and the co-treatment with isoflavones was able to reduce the levels of IL-1β and TNF-α, but not IL-6.
It is believed that the beneficial effect found with this alternative treatment is related to its anti-inflammatory potential and to the action on estrogen receptors (based on scientific literature findings). Finally, further studies are needed to elucidate the mechanisms of isoflavones in reducing motor disorders induced by antipsychotics.
精神分裂症是一种精神疾病，其药物治疗包括使用抗精神病药物，如氟哌啶醇。然而，氟哌啶醇常引起锥体外系运动障碍，如迟发性运动障碍（TD）。到目前为止，尚无针对TD的有效治疗方法，因此一直在寻找替代方案。异黄酮已被研究作为神经保护剂和单胺氧化酶抑制剂。因此，目的是评估异黄酮在动物模型中对氟哌啶醇诱导的不自主运动的可能保护作用。
雄性Wistar大鼠用氟哌啶醇（1mg/kg/天）和/或异黄酮（80mg/kg）治疗28天。对大鼠进行行为评估，以量化空嚼运动（VCM）和运动活性。此外，还测量了纹状体中促炎细胞因子的水平。氟哌啶醇治疗降低了大鼠的运动活性，并增加了VCM的数量。异黄酮联合治疗能够逆转运动减少并减少VCM的数量。此外，氟哌啶醇导致促炎细胞因子（白细胞介素-1β：IL-1β、肿瘤坏死因子-α：TNF-α和IL-6）显著增加，而异黄酮联合治疗能够降低IL-1β和TNF-α的水平，但不能降低IL-6的水平。
据信，这种替代治疗发现的有益效果与其抗炎潜力以及对雌激素受体的作用有关（基于科学文献研究结果）。最后，需要进一步研究以阐明异黄酮减少抗精神病药物诱导的运动障碍的机制。
