Toyota T, Kakizaki M, Kimura K, Yajima M, Okamoto T, Ui M
Diabetologia. 1978 May;14(5):319-23. doi: 10.1007/BF01223023.
The early phase of insulin secretion to an oral glucose load was blunted in spontaneous diabetic rats. The blunted insulin secretion was associated with markedly impaired glucose tolerance. A single injection of the islet activating protein (IAP), a protein derived from the culture medium of Bordetella pertussis, into the spontaneous diabetic rats normalised glucose tolerance. The increase in insulin response to glucose was an important contributing factor to the improvement of glucose tolerance. This curative effect of the IAP on the diabetic state was of long duration; glucose tolerance remained virtually normal over a period of one month in the diabetic rats. Perfusion of the isolated pancreas of the diabetic rats pretreated with IAP showed an increase in insulin response to glucose and loss of suppression of glucagon secretion by noradrenaline.
自发性糖尿病大鼠对口服葡萄糖负荷的早期胰岛素分泌减弱。胰岛素分泌减弱与葡萄糖耐量显著受损有关。向自发性糖尿病大鼠单次注射源自百日咳博德特氏菌培养基的胰岛激活蛋白（IAP）可使葡萄糖耐量恢复正常。胰岛素对葡萄糖反应的增加是葡萄糖耐量改善的一个重要促成因素。IAP对糖尿病状态的这种治疗效果持续时间长；糖尿病大鼠在一个月的时间里葡萄糖耐量几乎保持正常。对用IAP预处理的糖尿病大鼠的离体胰腺进行灌注，结果显示胰岛素对葡萄糖的反应增加，去甲肾上腺素对胰高血糖素分泌的抑制作用丧失。
