Clinical Research Division, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Psychiatry Department, New York University School of Medicine, New York, NY, USA.
World J Biol Psychiatry. 2022 Jul;23(6):456-463. doi: 10.1080/15622975.2021.2013042. Epub 2021 Dec 15.
Previous studies have demonstrated elevated levels of the S100B protein (located in glial cells) in major depressive disorder (MDD) as compared to healthy controls. However, studies reporting correlation between S100B levels and depression severity have been conflicting.
We investigated, through systematic review and meta-analysis, whether the correlation between S100B levels and depression severity is significant in patients with MDD. Pearson correlation coefficients reported in the individual studies were converted to Fisher's Z scores, then pooled using the random effects model. Meta-regression was used to test modifiers of the effect size.
Sixteen studies including 658 patients with MDD met eligibility criteria. No publication bias was observed. There was a significant and positive correlation between serum S100B level and depression severity ( = 0.204, = 2.297, = 0.022). A meta-regression determined that onset age of MDD and percentage of female participants are significant modifiers of this correlation. A moderate, but non-significant heterogeneity was observed in serum studies (44%).
As many studies have reported significantly increased levels of S100B in MDD compared to controls, this meta-analysis supports the assumption that the increase in S100B correlates with the severity of MDD. Additional studies investigating the precise biological connection between S100B and MDD are indicated.
先前的研究表明，与健康对照组相比，重度抑郁症（MDD）患者的 S100B 蛋白（位于神经胶质细胞中）水平升高。然而，关于 S100B 水平与抑郁严重程度之间相关性的研究结果存在争议。
我们通过系统综述和荟萃分析，研究 S100B 水平与 MDD 患者抑郁严重程度之间的相关性是否显著。将个体研究中报告的 S100B 水平与抑郁严重程度的 Pearson 相关系数转换为 Fisher Z 分数，然后使用随机效应模型进行汇总。使用元回归来检验效应大小的调节因素。
纳入了 16 项研究，共 658 名 MDD 患者符合入选标准。未观察到发表偏倚。血清 S100B 水平与抑郁严重程度呈显著正相关（ = 0.204， = 2.297， = 0.022）。元回归确定 MDD 的发病年龄和女性参与者的百分比是该相关性的显著调节因素。在血清研究中观察到中度但无统计学意义的异质性（44%）。
由于许多研究报告 MDD 患者的 S100B 水平明显高于对照组，因此该荟萃分析支持这样一种假设，即 S100B 的增加与 MDD 的严重程度相关。需要进一步研究来探讨 S100B 与 MDD 之间的确切生物学联系。
