Donadio C
J Int Med Res. 1986;14(1):50-2.
Twenty patients with documented T. vaginalis infections, six of whom were simultaneously infected with C. albicans and one with G. vaginalis, were treated topically (intravaginally) once daily with 5 g of 2% tioconazole vaginal cream (Trosyd, Pfizer) for 3 consecutive days in an open, non-comparative study. At the first follow-up visit (about 7 days post-treatment), 95% (19/20) of the patients were cured; 95% (18/19) of patients remained cured with respect to the baseline infection at the long-term follow-up (2 months post-treatment) visit, and one patient had a reinfection or relapse with T. vaginalis. Only one patient reported a side-effect, a mild vaginal burning which disappeared with continued treatment. It was concluded that tioconazole 2% vaginal cream is safe and effective for the treatment of T. vaginalis and mixed vaginal infections.
20例确诊为阴道毛滴虫感染的患者，其中6例同时感染白色念珠菌，1例感染阴道加德纳菌，在一项开放性、非对照研究中，连续3天每天阴道局部使用5g 2%的噻康唑阴道乳膏（Trosyd，辉瑞公司）进行治疗。在首次随访（治疗后约7天）时，95%（19/20）的患者治愈；在长期随访（治疗后2个月）时，95%（18/19）的患者相对于基线感染仍保持治愈状态，1例患者出现阴道毛滴虫再感染或复发。只有1例患者报告有副作用，即轻度阴道烧灼感，继续治疗后消失。得出结论，2%噻康唑阴道乳膏治疗阴道毛滴虫及混合性阴道感染安全有效。
