International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
Systems Bioengineering, DCEXS, Universidad Pompeu Fabra, Doctor Aiguader, 88 ICREA, Pag Lluis Companys 23, Barcelona, Spain.
Science. 2021 Dec 3;374(6572):abg1727. doi: 10.1126/science.abg1727.
The primitive streak, a transient embryonic structure, marks bilateral symmetry in mammalian and avian embryos and helps confer anterior-posterior and dorsal-ventral spatial information to early differentiating cells during gastrulation. Its recapitulation in vitro may facilitate derivation of tissues and organs with in vivo–like complexity. Proper understanding of the primitive streak and what it entails in human development is key to achieving such research objectives. Here we provide an overview of the primitive streak and conclude that this structure is neither conserved nor necessary for gastrulation or early lineage diversification. We offer a model in which the primitive streak is viewed as part of a morphologically diverse yet molecularly conserved process of spatial coordinate acquisition. We predict that recapitulation of the primitive streak is dispensable for development in vitro.
原肠胚，一种短暂的胚胎结构，标志着哺乳动物和禽类胚胎的两侧对称性，并在原肠胚形成过程中帮助早期分化的细胞获得前后和背腹空间信息。它在体外的再现可能有助于获得具有体内样复杂性的组织和器官。正确理解原肠胚及其在人类发育中的作用是实现这些研究目标的关键。在这里，我们提供了原肠胚的概述，并得出结论，该结构对于原肠胚形成或早期谱系多样化既没有保守性也不是必需的。我们提出了一个模型，其中原肠胚被视为空间坐标获取的形态多样但分子保守过程的一部分。我们预测，体外发育中不需要再现原肠胚。
