Department of neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Neurologist. 2022 Sep 1;27(5):230-234. doi: 10.1097/NRL.0000000000000392.
As a common complication of cerebral infarction, hemorrhagic transformation (HT) often indicates a worse clinical outcome. The aim of this study was to explore the relationship between the platelet-to-neutrophil ratio (PNR) and HT in patients with acute cerebral infarction.
Patients with HT after acute cerebral infarction were enrolled in the HT group. Matched patients with acute cerebral infarction without HT were enrolled at the same time. All patients included in this study did not receive reperfusion therapy. The PNR was obtained on the second day of admission. Multivariate logistic analysis was used to evaluate the relationship between the PNR and HT.
We collected data from a total of 137 patients: 61 patients with HT and 76 patients without HT. After adjusting for confounders, the PNR was independently associated with HT (odds ratio=0.922, 95% confidence interval: 0.891-0.955, P <0.05). The receiver operating characteristic curve demonstrated that the PNR could better predict HT (area under the curve=0.808, 95% confidence interval: 0.735-0.882, P <0.05). When the cut-off value of the PNR was 50.4765, the sensitivity was 70.5%, and the specificity was 82.9%. After stratifying the PNR to 50.4765, logistic analysis was performed again. The risk of HT in patients with a low PNR was 12.995 times that of patients with a high PNR. In patients without atrial fibrillation, the PNR was still independently related to HT.
The PNR is a predictor of HT, and patients with a low PNR have a higher risk of HT.
作为脑梗死的常见并发症，出血性转化（HT）常预示着更差的临床结局。本研究旨在探讨血小板与中性粒细胞比值（PNR）与急性脑梗死患者 HT 的关系。
纳入急性脑梗死发生 HT 的患者为 HT 组，同期纳入急性脑梗死未发生 HT 的匹配患者为非 HT 组，所有纳入患者均未接受再灌注治疗，于入院第 2 天行 PNR 检测。采用多因素 logistic 分析评估 PNR 与 HT 的关系。
共纳入 137 例患者，其中 HT 组 61 例，非 HT 组 76 例。校正混杂因素后，PNR 与 HT 独立相关（比值比=0.922，95%置信区间：0.8910.955，P<0.05）。受试者工作特征曲线表明，PNR 可更好地预测 HT（曲线下面积=0.808，95%置信区间：0.7350.882，P<0.05）。当 PNR 的截断值为 50.4765 时，灵敏度为 70.5%，特异度为 82.9%。将 PNR 分层至 50.4765 后再次行 logistic 分析，低 PNR 患者发生 HT 的风险是高 PNR 患者的 12.995 倍。在无房颤的患者中，PNR 仍与 HT 独立相关。
PNR 是 HT 的预测指标，低 PNR 患者 HT 风险更高。
