四种不同磺胺类药物与甲氧苄啶联用在人类志愿者中的比较药代动力学研究。

Comparative pharmacokinetic study of four different sulfonamides in combination with trimethoprim in human volunteers.

作者信息

Garg S K, Ghosh S S, Mathur V S

出版信息

Int J Clin Pharmacol Ther Toxicol. 1986 Jan;24(1):23-5.

Abstract

The pharmacokinetics of four different sulfonamides i. e., sulfamethoxazole (SMZ). Sulfamoxole (SMO), Sulfadiazine (SDZ) and Sulfadimidine (SDD) in combination with trimethoprim (TMP) were studied in 12 healthy volunteers. Plasma and urine concentrations of sulfonamides were measured at different time intervals. No significant difference was observed in the area under the plasma curve (AUC) of SMZ, SMO and SDZ, while AUC of SMO was significantly higher than SDD only. Free (unmetabolized) SDZ urinary excretion during a 10-25 h period was significantly higher than SMZ, SMO and SDD. The results suggest that SDZ alone or in combination with TMP would be more effective in urinary tract infections as compared to other sulfonamides studied.

摘要

在12名健康志愿者中研究了四种不同磺胺类药物，即磺胺甲恶唑（SMZ）、磺胺异恶唑（SMO）、磺胺嘧啶（SDZ）和磺胺二甲嘧啶（SDD）与甲氧苄啶（TMP）联合使用时的药代动力学。在不同时间间隔测量磺胺类药物的血浆和尿液浓度。磺胺甲恶唑、磺胺异恶唑和磺胺嘧啶的血浆曲线下面积（AUC）未观察到显著差异，而仅磺胺异恶唑的AUC显著高于磺胺二甲嘧啶。在10 - 25小时期间，游离（未代谢）磺胺嘧啶的尿排泄量显著高于磺胺甲恶唑、磺胺异恶唑和磺胺二甲嘧啶。结果表明，与所研究的其他磺胺类药物相比，单独使用磺胺嘧啶或与甲氧苄啶联合使用在治疗尿路感染方面可能更有效。