Naber K, Vergin H, Weigand W
Infection. 1981;9(5):239-43. doi: 10.1007/BF01640724.
Following a single dose of co-trimoxazole or co-tetroxazine, the plasma and urine levels of intact trimethoprim (TMP) and sulphamethoxazole (SMZ) and of tetroxoprim and sulphadiazine (SDZ) were determined in six geriatric patients in a cross-over design by high pressure liquid chromatography. The pharmacokinetic analysis showed a plasma elimination half-life in the terminal phase of 10.39 h for TMP, 11.79 h for SMZ, 6.55 h for TXP and 10.46 h for SDZ. The resulting distribution volumes Vd beta and total plasma clearance values corresponded with the data obtained in young patients or volunteers. Recovery in urine, measured for up to 96 h, was 49.2% (TMP), 19.8% (SMZ), 57.03% (TXP) and 61.1% (SDZ). In contrast to young volunteers, geriatric patients experienced a slight prolongation of renal excretion for both sulphonamides. In this group of patients the renal clearance was 2.42 ml/min for SMZ and 10.7 ml/min for SDZ.
在一项交叉设计中，通过高压液相色谱法测定了6名老年患者单次服用复方新诺明或复方四氧嘧啶后，血浆和尿液中完整甲氧苄啶（TMP）、磺胺甲恶唑（SMZ）以及四氧普明和磺胺嘧啶（SDZ）的水平。药代动力学分析显示，TMP在终末相的血浆消除半衰期为10.39小时，SMZ为11.79小时，TXP为6.55小时，SDZ为10.46小时。所得分布容积Vdβ和总血浆清除率值与年轻患者或志愿者的数据一致。长达96小时的尿液回收率分别为：TMP 49.2%、SMZ 19.8%、TXP 57.03%、SDZ 61.1%。与年轻志愿者不同，老年患者的两种磺胺类药物肾排泄均略有延长。在该组患者中，SMZ的肾清除率为2.42 ml/min，SDZ为10.7 ml/min。
