A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis.
作者信息
Lehmann A R, Arlett C F, Burke J F, Green M H, James M R, Lowe J E
出版信息
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Apr;49(4):639-43. doi: 10.1080/09553008514552881.
PMID:3485605
Abstract
Ataxia-telangiectasia (A-T) cells are hypersensitive to the lethal effects of ionizing radiation and fail to inhibit DNA synthesis following radiation exposure. A cell line derived from an A-T line following DNA-mediated gene transfer has normal radiation sensitivity, but the kinetics of DNA synthesis after gamma-irradiation are similar to those of A-T cells.
摘要
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