Department of Medicine, PH8-864, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Osteoporos Int. 2010 Feb;21(2):263-73. doi: 10.1007/s00198-009-0945-7. Epub 2009 May 20.
We compared microarchitecture and mechanical competence parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite-element analysis of radius and tibia to those measured by histomorphometry, micro-CT, and finite-element analysis of transiliac bone biopsies. Correlations were weak to moderate between parameters measured on biopsies and scans.
HR-pQCT is a new imaging technique that assesses trabecular and cortical bone microarchitecture of the radius and tibia in vivo. The purpose of this study was to determine the extent to which microarchitectural variables measured by HR-pQCT reflect those measured by the "gold standard," transiliac bone biopsy.
HR-pQCT scans (Xtreme CT, Scanco Medical AG) and iliac crest bone biopsies were performed in 54 subjects (aged 39 +/- 10 years). Biopsies were analyzed by 2D quantitative histomorphometry and 3D microcomputed tomography (microCT). Apparent Young's modulus, an estimate of mechanical competence or strength, was determined by micro-finite-element analysis (microFE) of biopsy microCT and HR-pQCT images.
The strongest correlations observed were between trabecular parameters (bone volume fraction, number, separation) measured by microCT of biopsies and HR-pQCT of the radius (R 0.365-0.522; P < 0.01). Cortical width of biopsies correlated with cortical thickness by HR-pQCT, but only at the tibia (R = 0.360, P < 0.01). Apparent Young's modulus calculated by microFE of biopsies correlated with that calculated for both radius (R = 0.442; P < 0.001) and tibia (R = 0.380; P < 0.001) HR-pQCT scans.
The associations between peripheral (HR-pQCT) and axial (transiliac biopsy) measures of microarchitecture and estimated mechanical competence are significant but modest.
我们比较了高分辨率外周定量计算机断层扫描（HR-pQCT）和桡骨及胫骨有限元分析测量的微结构和机械能力参数与骨活检的组织形态计量学、微 CT 和有限元分析测量的参数。活检和扫描测量的参数之间的相关性弱至中度。
HR-pQCT 是一种新的成像技术，可评估桡骨和胫骨的小梁和皮质骨微结构。本研究的目的是确定 HR-pQCT 测量的微结构变量在多大程度上反映了髂嵴骨活检的“金标准”。
对 54 名受试者（年龄 39±10 岁）进行 HR-pQCT 扫描（Xtreme CT，Scanco Medical AG）和髂嵴骨活检。通过 2D 定量组织形态计量学和 3D 微计算机断层扫描（microCT）对活检进行分析。通过微 CT 活检和 HR-pQCT 图像的微有限元分析（microFE）确定表观杨氏模量，这是机械能力或强度的估计值。
观察到的最强相关性是活检微 CT 测量的小梁参数（骨体积分数、数量、分离）与桡骨 HR-pQCT 之间的相关性（R 0.365-0.522；P<0.01）。活检的皮质宽度与 HR-pQCT 的皮质厚度相关，但仅在胫骨（R=0.360，P<0.01）。通过微 CT 活检的微 FE 计算得出的表观杨氏模量与桡骨（R=0.442；P<0.001）和胫骨（R=0.380；P<0.001）HR-pQCT 扫描计算出的表观杨氏模量相关。
外周（HR-pQCT）和轴向（髂嵴骨活检）微结构和估计机械能力的测量之间的关联是显著的，但适度的。
