Department of Spine and Osteopathy Ward, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, PR China.
Guangxi Medical University, No.22 Shuangyong Road, Nanning, Guangxi, PR China.
Tuberculosis (Edinb). 2022 Jan;132:102140. doi: 10.1016/j.tube.2021.102140. Epub 2021 Oct 28.
This study was aimed to reveal the role of ferroptosis in tuberculosis infection. To elucidate the ferroptosis-related DEGs, GEO datasets associated with tuberculosis infection were downloaded. The two external validation GEO datasets were exploited for subsequent verification of the ferroptosis-related DEGs. We further evaluated the correlation among the ferroptosis-related DEGs, therapeutic effects, and drug resistance. Finally, we tried to reveal the engagement of the ferroptosis-related DEGs in bone destruction during TB infection. The present study identified SOCS1 as the only ferroptosis-related DEGs. Compared to the non-TB patients, up-regulation of SOCS1 was evident in the TB patients. After receiving standard anti-TB treatment, significant down-regulation of SOCS1 confirmed its acceptance as the marker for therapeutic efficacy. The involvement of SOCS1 has also been suggested in the regulation of the micro immune environment in TB. Furthermore, SOCS1 might play an important role in causing bone destruction during TB infection. FRGs-SOCS1 may be the key gene involved in the pathogenesis and progression of TB infection.
本研究旨在揭示铁死亡在结核病感染中的作用。为了阐明与铁死亡相关的差异表达基因（DEGs），我们下载了与结核病感染相关的 GEO 数据集。我们利用两个外部验证的 GEO 数据集对与铁死亡相关的 DEGs 进行了后续验证。我们进一步评估了铁死亡相关 DEGs 与治疗效果和耐药性之间的相关性。最后，我们试图揭示铁死亡相关 DEGs 在结核病感染过程中骨破坏中的作用。本研究确定 SOCS1 为唯一的铁死亡相关 DEGs。与非结核病患者相比，结核病患者中 SOCS1 的表达明显上调。接受标准抗结核治疗后，SOCS1 的显著下调证实了其作为治疗效果标志物的接受程度。SOCS1 的参与也被认为与结核病中的微免疫环境调节有关。此外，SOCS1 在结核病感染过程中引起骨破坏的过程中可能发挥重要作用。FRGs-SOCS1 可能是参与结核病感染发病机制和进展的关键基因。
