Dawi John, Mohan Aishvaryaa Shree, Misakyan Yura, Affa Scarlet, Gonzalez Edgar, Hajjar Karim, Nikoghosyan David, Fardeheb Sabrina, Tuohino Christopher, Venketaraman Vishwanath
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Los Angeles Valley College, Valley Glen, CA 91401, USA.
Diseases. 2024 Feb 29;12(3):50. doi: 10.3390/diseases12030050.
Meningitis is an inflammatory condition affecting the meninges surrounding the brain and spinal cord. Meningitis can be triggered by various factors, including infectious agents like viruses and bacteria and non-infectious contributors such as cancer or head injuries. The impact of meningitis on the central nervous system involves disruptions in the blood-brain barrier, cellular infiltrations, and structural alterations. The clinical features that differentiate between tuberculous meningitis (TBM) and non-tuberculous meningitis (NTM) are discussed in this review and aid in accurate diagnosis. The intricate interplay of reactive oxygen species, ferroptosis, and reactive nitrogen species within the central nervous system reveals a promising field of research for innovative therapeutic strategies tailored to TBM. This review highlights the alternative treatments targeting oxidative stress-induced TBM and ferroptosis, providing potential avenues for intervention in the pathogenesis of this complex condition.
脑膜炎是一种影响大脑和脊髓周围脑膜的炎症性疾病。脑膜炎可由多种因素引发，包括病毒和细菌等感染因子以及癌症或头部受伤等非感染性因素。脑膜炎对中枢神经系统的影响包括血脑屏障破坏、细胞浸润和结构改变。本综述讨论了结核性脑膜炎（TBM）和非结核性脑膜炎（NTM）之间的临床特征差异，有助于准确诊断。中枢神经系统内活性氧、铁死亡和活性氮之间复杂的相互作用揭示了一个有前景的研究领域，即针对TBM的创新治疗策略。本综述强调了针对氧化应激诱导的TBM和铁死亡的替代治疗方法，为干预这种复杂疾病的发病机制提供了潜在途径。
