Birnbaum G, Kotilinek L, Schwartz M, Sternad M
J Neuroimmunol. 1986 May;11(3):237-43. doi: 10.1016/0165-5728(86)90007-x.
Spinal fluid and peripheral blood lymphocytes from patients with multiple sclerosis (MS) and other neurologic diseases (OND) were stimulated with a pool of allogeneic MS lymphocytes. Responding cells were cloned and assayed for their proliferative responses to peripheral blood lymphocytes from monozygotic twins discordant for MS. As expected, most (greater than 90%) responding clones proliferated equally well to cells from both members of a twin set. However, some clones were noted that responded to cells from one but not the other of the twin set. These differences could not be explained on the basis of a decreased stimulatory capacity of the twin cells. We cannot definitively explain our observations but they may suggest that environmental factors, perhaps exposure to a virus, could have altered the antigenic phenotypes of cells from identical twins discordant for MS. Further evaluation of the nature of these differences may lead to an understanding of the pathogenesis of the disease.
来自多发性硬化症（MS）患者和其他神经系统疾病（OND）患者的脑脊液和外周血淋巴细胞，用一组同种异体MS淋巴细胞进行刺激。对反应细胞进行克隆，并检测它们对来自同卵双胞胎中患MS与未患MS的一方的外周血淋巴细胞的增殖反应。正如预期的那样，大多数（超过90%）反应性克隆对双胞胎中两人的细胞增殖能力相同。然而，发现一些克隆对双胞胎中一方的细胞有反应，而对另一方的细胞无反应。这些差异不能用双胞胎细胞刺激能力降低来解释。我们无法确切解释我们的观察结果，但它们可能表明环境因素，也许是接触病毒，可能改变了同卵双胞胎中患MS与未患MS的一方细胞的抗原表型。对这些差异本质的进一步评估可能会有助于理解该疾病的发病机制。
