Department of Pathology, Pudong New Area People\'s Hospital, Shanghai, 201299, China.
Department of Pathophysiology, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
Recent Pat Anticancer Drug Discov. 2022;17(3):231-243. doi: 10.2174/1574892816666211202160041.
(su(var)-3-9,enhancer-of-zeste,trithorax) domain-containing protein 7/9 (SET7/9) is a member of the protein lysine methyltransferases (PLMTs or PKMTs) family. It contains a SET domain. Recent studies demonstrate that SET7/9 methylates both lysine 4 of histone 3 (H3-K4) and lysine(s) of non-histone proteins, including transcription factors, tumor suppressors, and membrane-associated receptors.
This article mainly reviews the non-histone methylation effects of SET7/9 and its functions in tumorigenesis and development.
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SET7/9 plays a key regulatory role in various biological processes such as cell proliferation, transcription regulation, cell cycle, protein stability, cardiac morphogenesis, and development. In addition, SET7/9 is involved in the pathogenesis of hair loss, breast cancer progression, human carotid plaque atherosclerosis, chronic kidney disease, diabetes, obesity, ovarian cancer, prostate cancer, hepatocellular carcinoma, and pulmonary fibrosis.
SET7/9 is an important methyltransferase, which can catalyze the methylation of a variety of proteins. Its substrates are closely related to the occurrence and development of tumors.
（su(var)-3-9、增强子的果蝇zeste、trithorax）结构域蛋白 7/9（SET7/9）是蛋白赖氨酸甲基转移酶（PLMTs 或 PKMTs）家族的一员。它含有一个 SET 结构域。最近的研究表明，SET7/9 甲基化组蛋白 3（H3-K4）赖氨酸 4 和非组蛋白蛋白的赖氨酸，包括转录因子、肿瘤抑制因子和膜相关受体。
本文主要综述 SET7/9 的非组蛋白甲基化作用及其在肿瘤发生发展中的功能。
通过 PubMed 检索相关信息。
SET7/9 在细胞增殖、转录调控、细胞周期、蛋白质稳定性、心脏形态发生和发育等多种生物学过程中发挥关键调节作用。此外，SET7/9 参与脱发、乳腺癌进展、人颈动脉斑块动脉粥样硬化、慢性肾脏病、糖尿病、肥胖、卵巢癌、前列腺癌、肝癌和肺纤维化的发病机制。
SET7/9 是一种重要的甲基转移酶，可以催化多种蛋白质的甲基化。其底物与肿瘤的发生发展密切相关。
