Cao Limin, Wang Min, Xu Ke
Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
Zhongguo Fei Ai Za Zhi. 2023 Jan 20;26(1):38-45. doi: 10.3779/j.issn.1009-3419.2023.106.02.
The occurence and development of tumors is a complicated process, which not only depends on the mutation or deletion of genes, but also is affected by epigenetic regulation. Accumulating evidences have shown that epigenetic modifications play fundamental roles in transcriptional regulation, heterochromatin formation, X chromosome inactivation, DNA damage response and tumor development. SET domain containing lysine methyltransferase 7 (SETD7) was initially identified as an important lysine methyltransferase, which methylated histone and non-histone proteins. These modifications play fundamental roles. Once this modification disorders, it can directly lead to cell abnormalities and cause many diseases. Studies have shown that SETD7 is related to the occurence and development of various tumors, but the methylation sites of SETD7 and its regulatory mechanism have not been fully elucidated. This article summarizes the research progress of the role of SETD7 on histone and non-histone methylation modification in tumors and the molecular mechanism, in order to provide new therapeutic targets for tumor pathogenesis and diagnosis. .
肿瘤的发生和发展是一个复杂的过程，它不仅取决于基因的突变或缺失，还受表观遗传调控的影响。越来越多的证据表明，表观遗传修饰在转录调控、异染色质形成、X染色体失活、DNA损伤反应和肿瘤发展中发挥着重要作用。含SET结构域的赖氨酸甲基转移酶7（SETD7）最初被鉴定为一种重要的赖氨酸甲基转移酶，它可使组蛋白和非组蛋白发生甲基化。这些修饰发挥着重要作用。一旦这种修饰紊乱，可直接导致细胞异常并引发多种疾病。研究表明，SETD7与多种肿瘤的发生和发展有关，但其甲基化位点及其调控机制尚未完全阐明。本文综述了SETD7在肿瘤中对组蛋白和非组蛋白甲基化修饰作用的研究进展及其分子机制，以期为肿瘤发病机制及诊断提供新的治疗靶点。
