Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei, 106, Taiwan, ROC.
Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei, 106, Taiwan, ROC.
Anal Chim Acta. 2022 Jan 15;1190:339234. doi: 10.1016/j.aca.2021.339234. Epub 2021 Nov 1.
In this work, pyrochlore neodymium stannate nanoparticles (NdSnO NP) have been synthesized by a facile co-precipitation technique and employed as an electrode material on GCE for the determination of dimetridazole (DM) drug. The physical properties and texture of the NdSnO NP were characterized by PXRD, Raman spectroscopy, FE-SEM, EDX mapping, XPS, and HR-TEM analytical studies. The electrocatalytic investigation of NdSnO NP/GCE was carried out by CV, and DPV techniques. The fabricated NdSnO NP/GCE shows a lower LOD of 6 nm towards the determination of DM and the calculated sensitivity is 0.61 μA μM cm. In addition to that, the constructed sensor delivers notable repeatability, reproducibility, and superior selectivity with the existence of metal ions, biological molecules, and nitro compounds, enabling the electrochemical detection of DM. Furthermore, NdSnO NP/GCE sensor displays acceptable recovery results in the real sample analysis in biological fluids such as human blood serum and human urine.
在这项工作中，通过简便的共沉淀技术合成了焦绿石钕锡酸纳米粒子（NdSnO NP），并将其用作 GCE 上的电极材料，用于测定二甲硝唑（DM）药物。通过 PXRD、拉曼光谱、FE-SEM、EDX 图谱、XPS 和 HR-TEM 分析研究对 NdSnO NP 的物理性质和结构进行了表征。通过 CV 和 DPV 技术对 NdSnO NP/GCE 的电催化性能进行了研究。制备的 NdSnO NP/GCE 对 DM 的测定表现出较低的 LOD（6nm），计算出的灵敏度为 0.61μAμMcm。此外，该构建的传感器在存在金属离子、生物分子和硝基化合物的情况下，表现出良好的重复性、重现性和优异的选择性，可用于 DM 的电化学检测。此外，NdSnO NP/GCE 传感器在生物体液（如人血清和人尿）中的实际样品分析中显示出可接受的回收率结果。
