二甲双胍可预测高强度间歇训练期间乳酸峰值，但不会改变业余游泳运动员的运动表现或神经肌肉反应。

Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers.

机构信息

University of São Paulo, Medical School of Ribeirão Preto (FMRP), Ribeirão Preto, São Paulo, Brazil; University of São Paulo, School of Physical Education and Sport of Ribeirão Preto (EEFERP-USP), Ribeirão Preto, São Paulo, Brazil.

University of São Paulo, School of Physical Education and Sport of Ribeirão Preto (EEFERP-USP), Ribeirão Preto, São Paulo, Brazil.

出版信息

Clin Nutr ESPEN. 2021 Dec;46:305-313. doi: 10.1016/j.clnesp.2021.09.739. Epub 2021 Oct 12.

DOI:10.1016/j.clnesp.2021.09.739

PMID:34857212

Abstract

BACKGROUND & AIMS: Metformin demonstrated potential to improve metabolic efficiency in short-intense and prolonged-continuous efforts. The present study investigates the acute effects of metformin intake on performance, rating of perceived exertion (RPE), blood lactate, blood glucose and neuromuscular parameters related to swimming high-intensity interval series.

METHODS

A double-blind, crossover, randomized and placebo-controlled study was carried out. Seven healthy swimmers ingested metformin (500 mg) or placebo capsules on different days and performed a typical high-intensity training series (10 bouts of 50 m with a 3-min interval). Performance, RPE, neuromuscular parameters (lower and upper limbs), blood lactate and glucose were analyzed by the Wilcoxon Signed-Rank and Friedman's tests between supplementation situations and moments, respectively (p > 0.05), the moment where glucose and blood lactate peak were found were analyzed by a Student t-test (p > 0.05) and a Bayesian repeated-measures ANOVA for effects analysis (BF).

RESULTS

The anticipation of blood glucose and peak lactate was signaling by the interaction effect (metformin increased and placebo decreased) between the eighth and the last bout (BF: 4.230 and 5.188 respectively). The second interaction effect of blood glucose and lactate (metformin maintained and placebo increased) during recoveries between 5 min and 7 min (BF: 3.825 and 3.806 respectively) also signaling the anticipatory behavior of both physiological parameters. The anticipation of blood lactate peak concentration after metformin intake confirms the anticipatory behavior of blood lactate (p: 0.015).

CONCLUSIONS

The anticipatory behavior of glucose was not confirmed. Although the anticipatory peak of blood lactate, metformin does not affect neuromuscular responses, RPE and performance.

REGISTRATION OF CLINICAL TRIAL

RBR-67wxdw8 Effects of metformin during swimmer training performance.

摘要

背景与目的

二甲双胍已被证明具有提高短时间剧烈运动和长时间连续运动代谢效率的潜力。本研究旨在探讨二甲双胍摄入对游泳高强度间歇训练系列中运动表现、感知用力程度（RPE）、血乳酸、血糖和与神经肌肉相关的参数的急性影响。

方法

进行了一项双盲、交叉、随机和安慰剂对照研究。7 名健康游泳运动员在不同的日子服用二甲双胍（500mg）或安慰剂胶囊，并进行了典型的高强度训练系列（10 个 50m 回合，间隔 3 分钟）。通过 Wilcoxon 符号秩和检验和 Friedman 检验分别分析补充情况和时间之间的运动表现、RPE、神经肌肉参数（上下肢）、血乳酸和血糖（p>0.05），通过学生 t 检验分析葡萄糖和血乳酸峰值出现的时间（p>0.05），并进行贝叶斯重复测量方差分析进行效应分析（BF）。

结果

血葡萄糖和峰值乳酸的预期是通过第八回合和最后回合之间的交互效应（二甲双胍增加，安慰剂减少）来指示的（BF：分别为 4.230 和 5.188）。恢复期间（第 5 分钟至第 7 分钟）血葡萄糖和乳酸的第二个交互效应（二甲双胍维持，安慰剂增加）也指示了这两个生理参数的预期行为（BF：分别为 3.825 和 3.806）。在服用二甲双胍后，血乳酸峰值浓度的预期行为证实了血乳酸的预期行为（p：0.015）。