Department of Anaesthesiology, School of Medicine, University of Colorado, Aurora, CO, USA.
Br J Anaesth. 2022 Feb;128(2):229-231. doi: 10.1016/j.bja.2021.10.032. Epub 2021 Nov 30.
Growing animal and clinical data continue to point to general anaesthetics as being potentially detrimental to the very young brain. While we are trying to understand the mechanisms responsible for this worrisome phenomenon, we must consider the value of protective strategies that would enable use of currently available general anaesthetics while avoiding histopathological changes and long-lasting impairment in behavioural and cognitive development. Wali and colleagues report that the gestational hormone progesterone is a promising 'safening' agent that ameliorates systemic inflammation caused by sevoflurane, a commonly used inhaled anaesthetic, while preventing development of cognitive impairment and an anxious phenotype.
越来越多的动物和临床数据表明，全身麻醉可能对非常年幼的大脑有害。当我们试图了解导致这种令人担忧现象的机制时，我们必须考虑采取保护策略的价值，这些策略可以使我们在避免组织病理学变化和行为及认知发育长期受损的情况下，使用现有的全身麻醉剂。Wali 等人报告称，妊娠激素孕酮是一种很有前途的“安全”药物，它可以改善七氟醚（一种常用的吸入性麻醉剂）引起的全身炎症，同时预防认知障碍和焦虑表型的发生。
