Division of Nephrology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
Sci Rep. 2021 Dec 2;11(1):23333. doi: 10.1038/s41598-021-02647-8.
To identify whether urolithiasis with or without hydronephrosis has an impact on acute kidney injury (AKI) in patients with urinary tract infection (UTI). This study aimed to identify whether urolithiasis with or without hydronephrosis has an impact on AKI in patients with UTI. This retrospective study enrolled hospitalized UTI patients who underwent imaging in an acute care setting from January 2006 to April 2019. Of the 1113 participants enrolled, 191 (17.2%) had urolithiasis and 76 (6.8%) had ureteral stone complicated with hydronephrosis. Multivariate logistic regression analysis showed that in UTI patients with urolithiasis, the presence of ureteral stone with concomitant hydronephrosis was an independent risk factor for AKI (odds ratio [OR] 2.299, 95% confidence interval [CI] 1.112-4.755, P = 0.025). In addition, urolithiasis was associated with an increased risk for AKI (OR 2.451, 95% CI 1.369-4.389, P = 0.003) in UTI patients without hydronephrosis. The presence of ureteral stone with hydronephrosis increases the risk for AKI of UTI patients with urolithiasis, and urolithiasis remains a risk factor of AKI in UTI patients without hydronephrosis.
确定有无肾积水的尿路结石是否会影响尿路感染（UTI）患者的急性肾损伤（AKI）。
本研究旨在确定有无肾积水的尿路结石是否会影响 UTI 患者的 AKI。
这项回顾性研究纳入了 2006 年 1 月至 2019 年 4 月在急症护理环境下进行影像学检查的住院 UTI 患者。在纳入的 1113 名参与者中，191 名（17.2%）患有尿路结石，76 名（6.8%）患有输尿管结石合并肾积水。
多变量逻辑回归分析显示，在患有尿路结石的 UTI 患者中，输尿管结石伴肾积水的存在是 AKI 的独立危险因素（比值比 [OR] 2.299，95%置信区间 [CI] 1.112-4.755，P=0.025）。此外，在无肾积水的 UTI 患者中，尿路结石与 AKI 的风险增加相关（OR 2.451，95%CI 1.369-4.389，P=0.003）。
输尿管结石伴肾积水增加了尿路结石合并 UTI 患者 AKI 的风险，而尿路结石仍是无肾积水 UTI 患者 AKI 的危险因素。
