Jamieson T
Postgrad Med. 1986 Apr;79(5):239-44. doi: 10.1080/00325481.1986.11699362.
Of the corticosteroid preparations available, the intermediate-acting agents are the preparations most commonly used in the rheumatic diseases. Careful tailoring of dosage is important to avoid adrenal atrophy and signs of adrenocortical hypofunction. The best regimen in a given patient depends on the amount of antiinflammatory and immunosuppressive activity required. The therapeutic strategies in use include pulse therapy, daily high-dose therapy, daily low-dose therapy, and alternate-day dosing. The latter two methods are preferable because of the decreased likelihood of adverse reactions, yet are not sufficient in cases of fulminant systemic inflammatory processes.
在现有的皮质类固醇制剂中，中效制剂是风湿性疾病中最常用的制剂。仔细调整剂量对于避免肾上腺萎缩和肾上腺皮质功能减退的体征很重要。特定患者的最佳治疗方案取决于所需的抗炎和免疫抑制活性量。目前使用的治疗策略包括冲击疗法、每日大剂量疗法、每日小剂量疗法和隔日给药。后两种方法更可取，因为不良反应的可能性降低，但在暴发性全身炎症过程中并不足够。
