Morand E F
Monash University Department of Medicine, Monash Medical Centre, Clayton, Australia.
Curr Opin Rheumatol. 1998 May;10(3):179-83. doi: 10.1097/00002281-199805000-00005.
As understanding of the role of endogenous corticosteroid production by the adrenal glands in rheumatologic diseases has increased, attempts to refine their use in accordance with this knowledge have been reported. Similarly, as understanding of the induction of bone loss by corticosteroids increases, trials of agents designed to antagonize these actions are reported. The lack of large-scale comparative studies means that the optimal method of use of corticosteroids and the optimal antiresorptive protocols have yet to be defined.
随着对肾上腺产生内源性皮质类固醇在风湿性疾病中作用的认识不断增加，已有报道称人们尝试根据这一认识来优化其使用方法。同样，随着对皮质类固醇诱导骨质流失的认识增加，也有关于旨在拮抗这些作用的药物试验的报道。缺乏大规模的比较研究意味着皮质类固醇的最佳使用方法和最佳抗吸收方案尚未确定。
