Li Xiao, Yu Renqiang, Huang Qian, Chen Xiaolu, Ai Ming, Zhou Yi, Dai Linqi, Qin Xiaoyue, Kuang Li
Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Hum Neurosci. 2021 Nov 11;15:762343. doi: 10.3389/fnhum.2021.762343. eCollection 2021.
Major depressive disorder (MDD) is one of the most widespread mental disorders and can result in suicide. Suicidal ideation (SI) is strongly predictive of death by suicide, and electroconvulsive therapy (ECT) is effective for MDD, especially in patients with SI. In the present study, we aimed to determine differences in resting-state functional magnetic resonance imaging (rs-fMRI) in 14 adolescents aged 12-17 with MDD and SI at baseline and after ECT. All participants were administered the Hamilton Depression Scale (HAMD) and Beck Scale for Suicide Ideation (BSSI) and received rs-fMRI scans at baseline and after ECT. Following ECT, the amplitude of low frequency fluctuation (ALFF) and fractional ALFF (fALFF) significantly decreased in the right precentral gyrus, and the degree centrality (DC) decreased in the left triangular part of the inferior frontal gyrus and increased in the left hippocampus. There were significant negative correlations between the change of HAMD (ΔHAMD) and ALFF in the right precentral gyrus at baseline, and between the change of BSSI and the change of fALFF in the right precentral gyrus. The ΔHAMD was positively correlated with the DC value of the left hippocampus at baseline. We suggest that these brain regions may be indicators of response to ECT in adolescents with MDD and SI.
重度抑郁症（MDD）是最普遍的精神障碍之一，可导致自杀。自杀意念（SI）是自杀死亡的强烈预测指标，而电休克疗法（ECT）对MDD有效，尤其是对有自杀意念的患者。在本研究中，我们旨在确定14名年龄在12至17岁的患有MDD和自杀意念的青少年在基线时以及ECT治疗后的静息态功能磁共振成像（rs-fMRI）差异。所有参与者均接受汉密尔顿抑郁量表（HAMD）和贝克自杀意念量表（BSSI）评估，并在基线时和ECT治疗后接受rs-fMRI扫描。ECT治疗后，右侧中央前回的低频振幅（ALFF）和分数低频振幅（fALFF）显著降低，左侧额下回三角部的度中心性（DC）降低，左侧海马的度中心性增加。基线时，右侧中央前回的HAMD变化量（ΔHAMD）与ALFF之间以及右侧中央前回的BSSI变化量与fALFF变化量之间存在显著负相关。基线时，ΔHAMD与左侧海马的DC值呈正相关。我们认为，这些脑区可能是患有MDD和自杀意念的青少年对ECT反应的指标。
