Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
Front Endocrinol (Lausanne). 2021 Nov 9;12:737624. doi: 10.3389/fendo.2021.737624. eCollection 2021.
Ectodysplasin A (EDA), a newly discovered hepatokine, has recently been considered to be closely related to glycolipid metabolism disorders, but the pathophysiological effects of EDA are still poorly understood. This study was the first time to determine the level of serum EDA in newly diagnosed type 2 diabetes mellitus (T2DM) patients, and to explore the relationships between serum EDA levels and various metabolic indexes.
A total of 184 subjects were enrolled in the study, including 92 subjects with newly diagnosed T2DM and 92 subjects with age- and sex-matched normal glucose tolerance (NGT). Serum EDA levels were determined using enzyme-linked immunosorbent assay (ELISA). Oral glucose tolerance test, glycosylated hemoglobin c (HbA1c), and insulin were also measured.
Serum EDA levels were significantly increased in the T2DM group than in the NGT group (359.91 ± 117.99 vs. 265.82 ± 86.51 pg/ml, < 0.001). Serum EDA levels were positively correlated with body mass index (BMI), waist-to-hip ratio (WHR), fasting plasma glucose (FPG), HbA1c, 2-hour postprandial plasma glucose (2hPG), fasting plasma insulin (FIns), fasting C peptide (FCP), triglyceride (TG), HOMA-IR, and negatively correlated with high-density lipoprotein cholesterol (HDL-c) and HOMA-β ( < 0.05). Multiple stepwise regression analysis demonstrated that 2hPG and FIns were independent influencing factors of serum EDA level ( < 0.05). Logistic regression analysis showed that serum EDA level was significantly independently correlated with T2DM ( < 0.05).
Serum EDA levels are significantly higher in T2DM patients, suggesting that EDA may play a role in the occurrence and development of T2DM.
外胚层发育不全 A （EDA）是一种新发现的肝源激素，最近被认为与糖脂代谢紊乱密切相关，但 EDA 的病理生理作用仍知之甚少。本研究首次测定了新诊断的 2 型糖尿病（T2DM）患者的血清 EDA 水平，并探讨了血清 EDA 水平与各种代谢指标之间的关系。
共纳入 184 例受试者，包括 92 例新诊断的 T2DM 患者和 92 例年龄和性别匹配的正常糖耐量（NGT）患者。采用酶联免疫吸附试验（ELISA）测定血清 EDA 水平。同时测定口服葡萄糖耐量试验、糖化血红蛋白 C（HbA1c）和胰岛素。
T2DM 组血清 EDA 水平明显高于 NGT 组（359.91±117.99 vs. 265.82±86.51 pg/ml，<0.001）。血清 EDA 水平与体重指数（BMI）、腰臀比（WHR）、空腹血糖（FPG）、HbA1c、餐后 2 小时血糖（2hPG）、空腹胰岛素（FIns）、空腹 C 肽（FCP）、甘油三酯（TG）、HOMA-IR 呈正相关，与高密度脂蛋白胆固醇（HDL-c）和 HOMA-β呈负相关（<0.05）。多元逐步回归分析表明，2hPG 和 FIns 是血清 EDA 水平的独立影响因素（<0.05）。Logistic 回归分析显示，血清 EDA 水平与 T2DM 显著独立相关（<0.05）。
T2DM 患者血清 EDA 水平明显升高，提示 EDA 可能在 T2DM 的发生发展中起作用。
