Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Department of Nephrology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
J Diabetes Res. 2023 Apr 12;2023:5087761. doi: 10.1155/2023/5087761. eCollection 2023.
Ectodysplasin A (EDA), a member of the TNF family, plays important roles in ectodermal development, while recent studies expanded its regulatory effects on insulin resistance and lipid metabolism. This study was the first time to investigate the correlation between circulating EDA and albuminuria in patients with T2DM.
A total of 189 T2DM and 59 healthy subjects were enrolled in the study. We analyzed the concentrations of EDA by ELISA. Plasma glucose, insulin, HbA1c, lipids, creatinine, BUN, and UACR were also measured. Insulin resistance and pancreatic cell function were assessed by HOMA.
Circulating EDA concentration was significantly increased in T2DM patients and increased with the degree of albuminuria. EDA was positively correlated with age, FIns, HOMA-IR, HOMA-, Scr, and UACR, and negatively correlated with eGFR. Linear stepwise regression showed that FIns, HOMA-, and UACR were independent influencing factors of EDA. Logistic regression analysis showed that EDA was independently associated with the occurrence of albuminuria in T2DM. ROC curve showed that EDA had an area under the receiver operating curve of 0.701 [95%CI = (0.625 - 0.777), < 0.001].
EDA is positively correlated with the degree of albuminuria in patients with T2DM and may be involved in the occurrence and progression of diabetic kidney disease (DKD).
表皮细胞分化因子 A（EDA）是 TNF 家族的成员，在表皮发育中发挥重要作用，而最近的研究扩展了其对胰岛素抵抗和脂质代谢的调节作用。本研究首次探讨了 2 型糖尿病（T2DM）患者循环 EDA 与白蛋白尿之间的相关性。
本研究共纳入 189 例 T2DM 患者和 59 名健康对照者。我们采用 ELISA 法检测 EDA 浓度。同时检测血浆葡萄糖、胰岛素、糖化血红蛋白（HbA1c）、血脂、肌酐、尿素氮（BUN）和尿白蛋白与肌酐比值（UACR）。采用 HOMA 评估胰岛素抵抗和胰岛β细胞功能。
T2DM 患者循环 EDA 浓度显著升高，并随白蛋白尿程度增加而升高。EDA 与年龄、FIns、HOMA-IR、HOMA-β、Scr 和 UACR 呈正相关，与 eGFR 呈负相关。线性逐步回归分析显示，FIns、HOMA-β和 UACR 是 EDA 的独立影响因素。Logistic 回归分析显示，EDA 与 T2DM 患者白蛋白尿的发生独立相关。ROC 曲线显示，EDA 的曲线下面积为 0.701[95%CI=（0.625-0.777）， < 0.001]。
EDA 与 T2DM 患者白蛋白尿程度呈正相关，可能参与糖尿病肾病（DKD）的发生和进展。
