Naguib Rania, Abouegylah Mohamed, Sharkawy Sherif, Fayed Amel A, Naguib Hend
Clinical Science Department, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, SAU.
Internal Medicine Department, Endocrinology Unit, Alexandria Faculty of Medicine, Alexandria, EGY.
Cureus. 2021 Nov 25;13(11):e19881. doi: 10.7759/cureus.19881. eCollection 2021 Nov.
BACKGROUND/AIM: Limited information is available about the relationship between colorectal cancer (CRC) and serum concentration of insulin-like growth factor 1 (IGF1) and insulin-like growth factor-binding protein 3 (IGFBP3). This study aims to compare the serum levels of IGF1and IGFBP3 in colorectal cancer cases and controls and to assess the relationship between their level and the demographic and histopathological characteristics.
A case-control study in which 50 patients with colorectal cancer and 50 controls matched by gender and age were compared regarding the demographic characteristics and the level of both IGF1 and IGFBP3. The correlation with different clinicopathological features was assessed.
Levels of IGF1 were significantly higher while levels of IGFBP3 were significantly lower among cases compared to control. IGF1 was significantly higher among patients with liver metastasis, lymph node (LN) spread, and lymphovenous invasions and did not show significant association with gender, smoking status, family history, or primary site of colorectal cancer. Lower IGFBP3 was significantly high among patients with liver and lymph node metastasis, lymphovenous invasion, and patients with positive family history. This significant negative correlation was also detected between IGFBP3 levels and the size of the tumor.
High IGF1 levels and low concentrations of IGFBP3 are related to colorectal cancer and were significantly associated with liver metastasis, lymph node spread, and lymphovenous invasions. Further research is recommended to investigate if circulating IGF1 and IGFBP3 levels can be used to identify people at high risk of colorectal cancer and to investigate potential lifestyle or pharmaceutical ways to lower IGF1 bioactivity as a risk reduction strategy.
背景/目的：关于结直肠癌（CRC）与胰岛素样生长因子1（IGF1）及胰岛素样生长因子结合蛋白3（IGFBP3）血清浓度之间的关系，目前可用信息有限。本研究旨在比较结直肠癌病例与对照者的IGF1和IGFBP3血清水平，并评估其水平与人口统计学及组织病理学特征之间的关系。
一项病例对照研究，比较了50例结直肠癌患者和50例按性别和年龄匹配的对照者的人口统计学特征以及IGF1和IGFBP3水平。评估了与不同临床病理特征的相关性。
与对照组相比，病例组的IGF1水平显著更高，而IGFBP3水平显著更低。在发生肝转移、淋巴结（LN）转移和淋巴血管浸润的患者中，IGF1显著更高，且与性别、吸烟状况、家族史或结直肠癌原发部位无显著关联。在发生肝转移和淋巴结转移、淋巴血管浸润的患者以及家族史阳性的患者中，较低的IGFBP3水平显著更高。在IGFBP3水平与肿瘤大小之间也检测到了这种显著的负相关。
高IGF1水平和低IGFBP3浓度与结直肠癌相关，且与肝转移、淋巴结转移和淋巴血管浸润显著相关。建议进一步研究以调查循环IGF1和IGFBP3水平是否可用于识别结直肠癌高危人群，并研究降低IGF1生物活性的潜在生活方式或药物方法作为降低风险的策略。
