一种用于测量比率荧光强度和磷光寿命的多功能多通道仪器。
A Versatile Multichannel Instrument for Measurement of Ratiometric Fluorescence Intensity and Phosphorescence Lifetime.
作者信息
Zavareh Amir Tofighi, Ko Brian, Roberts Jason, Elahi Sakib, McShane Michael J
机构信息
Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.
出版信息
IEEE Access. 2021;9:103835-103849. doi: 10.1109/access.2021.3098777. Epub 2021 Jul 21.
Optical biosensing is being actively investigated for minimally-invasive monitoring of key biomarkers both and . However, typical benchtop instruments are not portable and are not well suited to high-throughput, real-time analysis. This paper presents a versatile multichannel instrument for measurement of emission intensity and lifetime values arising from luminescent biosensor materials. A detailed design description of the opto-electronic hardware as well as the control software is provided, elaborating a flexible, user-configurable system that may be customized or duplicated for a wide range of applications. This article presents experimental measurements that prove the and functionality of the system. Such tools may be adopted for many research and development purposes, including evaluation of new biosensor materials, and may also serve as prototypes for future miniaturized handheld or wearable devices.
光学生物传感正在积极研究中，用于对体内和体外关键生物标志物进行微创监测。然而，典型的台式仪器不便于携带，也不太适合高通量实时分析。本文介绍了一种多功能多通道仪器，用于测量发光生物传感器材料产生的发射强度和寿命值。提供了光电硬件以及控制软件的详细设计描述，阐述了一个灵活的、用户可配置的系统，该系统可针对广泛的应用进行定制或复制。本文给出了实验测量结果，证明了该系统的体内和体外功能。此类工具可用于许多研发目的，包括评估新型生物传感器材料，还可作为未来小型手持或可穿戴设备的原型。
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