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插入型纳米复合水凝胶基磷光氧生物传感器的长期评估：局部组织氧水平和异物反应的演变。

Long-Term Evaluation of Inserted Nanocomposite Hydrogel-Based Phosphorescent Oxygen Biosensors: Evolution of Local Tissue Oxygen Levels and Foreign Body Response.

机构信息

Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, United States.

Department of Veterinary Anatomy and Pathobiology, Texas A&M University, College Station, Texas 77843, United States.

出版信息

ACS Appl Bio Mater. 2024 Jun 17;7(6):3964-3980. doi: 10.1021/acsabm.4c00336. Epub 2024 May 29.

DOI:10.1021/acsabm.4c00336
PMID:38809780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11190996/
Abstract

Phosphorescence-based oxygen-sensing hydrogels are a promising platform technology for an upcoming generation of insertable biosensors that are smaller, softer, and potentially more biocompatible than earlier designs. However, much remains unknown about their long-term performance and biocompatibility . In this paper, we design and evaluate a range of hydrogel sensors that contain oxygen-sensitive phosphors stabilized by micro- and nanocarrier systems. These devices demonstrated consistently good performance and biocompatibility in young adult rats for over three months. This study thoroughly establishes the biocompatibility and long-term suitability of phosphorescence lifetime sensors , providing the groundwork for expansion of this platform technology into a family of small, unobtrusive biosensors for a range of clinically relevant metabolites.

摘要

基于磷光的氧敏水凝胶是一种很有前途的平台技术，可用于新一代可插入式生物传感器，其比早期设计的传感器更小、更柔软，并且具有潜在更好的生物相容性。然而，关于它们的长期性能和生物相容性，仍有许多未知之处。在本文中，我们设计并评估了一系列含有由微载体和纳米载体系统稳定的氧敏荧光粉的水凝胶传感器。这些设备在年轻成年大鼠中超过三个月的时间内表现出一致的良好性能和生物相容性。这项研究彻底确立了磷光寿命传感器的生物相容性和长期适用性，为将该平台技术扩展为一系列用于多种临床相关代谢物的小型、不显眼的生物传感器家族奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/b3bebe7b0e67/mt4c00336_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/bd50a7da87e7/mt4c00336_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/d0143ac6136e/mt4c00336_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/7bd43eb02bde/mt4c00336_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/5132b8e7e34c/mt4c00336_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/6dc10bb6d2a9/mt4c00336_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/695ee3ebcc90/mt4c00336_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/3a0141b40708/mt4c00336_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/b3bebe7b0e67/mt4c00336_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/bd50a7da87e7/mt4c00336_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/d0143ac6136e/mt4c00336_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/7bd43eb02bde/mt4c00336_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/5132b8e7e34c/mt4c00336_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/6dc10bb6d2a9/mt4c00336_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/695ee3ebcc90/mt4c00336_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/3a0141b40708/mt4c00336_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/11190996/b3bebe7b0e67/mt4c00336_0008.jpg

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2
NIR Luminescent Oxygen-Sensing Nanoparticles for Continuous Glucose and Lactate Monitoring.用于连续血糖和乳酸监测的近红外发光氧传感纳米颗粒。
Biosensors (Basel). 2023 Jan 14;13(1):141. doi: 10.3390/bios13010141.
3
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Nat Biomed Eng. 2023 Dec;7(12):1541-1555. doi: 10.1038/s41551-022-00998-9. Epub 2023 Jan 19.
4
Geometry design for a fully insertable glucose biosensor with multimodal optical readout.具有多模光读取功能的全可插入葡萄糖生物传感器的几何设计。
J Biomed Opt. 2022 Nov;27(11). doi: 10.1117/1.JBO.27.11.117001.
5
Translational gaps and opportunities for medical wearables in digital health.医疗可穿戴设备在数字健康领域中的转化差距与机遇。
Sci Transl Med. 2022 Oct 12;14(666):eabn6036. doi: 10.1126/scitranslmed.abn6036.
6
Monte Carlo method for assessment of a multimodal insertable biosensor.用于评估多模态可插入生物传感器的蒙特卡罗方法。
J Biomed Opt. 2022 May;27(8). doi: 10.1117/1.JBO.27.8.083017.
7
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9
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Biosensors (Basel). 2020 Jul 21;10(7):79. doi: 10.3390/bios10070079.