Ruano-Ravina Alberto, Provencio Mariano, Calvo de Juan Virginia, Carcereny Enric, Estival Anna, Rodríguez-Abreu Delvys, Benítez Gretel, López-Castro Rafael, Belver Marta, Guirado-Risueño María, Guirao-Rubio Carlos, Blasco Ana, Massutí Bartomeu, Ortega Ana Laura, Cobo Manuel, Mosquera-Martínez Joaquín, Aguado de la Rosa Carlos, Bosch-Barrera Joaquim, Sánchez-Gastaldo Amparo, Del Barco Morillo Edel, Juan Óscar, Dómine Manuel, Trigo José Manuel, Pereiro Corbacho Diego, Oramas Juana
Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain.
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología and Salud Pública/CIBERESP), Madrid, Spain.
Transl Lung Cancer Res. 2021 Oct;10(10):3902-3911. doi: 10.21037/tlcr-21-559.
Lung cancer causes approximately 25% of all cancer deaths. Despite its relevance, few studies have analyzed differences by sex at the time of diagnosis in terms of symptoms, stage, age or smoking status. We aim to assess if there are differences between men and women on these characteristics at diagnosis.
We analyzed the Thoracic Tumour Registry (TTR), sponsored by the Spanish Lung Cancer Group using a case-series design. This is a nationwide registry of lung cancer cases which started recruitment in 2016. For each case included, clinicians fulfilled an electronic record registering demographic data, symptoms, exposure to lung cancer risk factors, and treatment received in detail. We compared men and women using descriptive statistics.
A total of 13,590 participants took part in this study, 25.6% women. Women were 4 years younger than men (64 69), and men had smoked more frequently. Adenocarcinoma was the most frequent histological type in both sexes. Stage IV at diagnosis was 50.8% in women compared to 43.6% in men. Weight loss/anorexia/asthenia was the most frequent symptom in both sexes and there were no differences in the number of symptoms at diagnosis. There were no relevant differences in the frequency or number of symptoms by sex when non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) were analyzed separately. Smoking status did not appear to cause different lung cancer presentation in men compared to women.
There seems to be no differences in lung cancer characteristics by sex at the time at diagnosis on stage, specific symptoms or number of symptoms.
肺癌导致约25%的癌症死亡。尽管其相关性较高，但很少有研究分析诊断时在症状、分期、年龄或吸烟状况方面的性别差异。我们旨在评估诊断时男性和女性在这些特征上是否存在差异。
我们使用病例系列设计分析了由西班牙肺癌小组赞助的胸肿瘤登记处（TTR）。这是一个全国性的肺癌病例登记处，于2016年开始招募。对于纳入的每个病例，临床医生填写一份电子记录，详细登记人口统计学数据、症状、肺癌危险因素暴露情况以及接受的治疗。我们使用描述性统计方法比较男性和女性。
共有13590名参与者参加了本研究，其中25.6%为女性。女性比男性年轻4岁（64对69岁），男性吸烟更频繁。腺癌是两性中最常见的组织学类型。女性诊断时IV期的比例为50.8%，男性为43.6%。体重减轻/厌食/乏力是两性中最常见的症状，诊断时症状数量没有差异。分别分析非小细胞肺癌（NSCLC）和小细胞肺癌（SCLC）时，症状的频率或数量在性别上没有相关差异。吸烟状况在男性和女性中似乎不会导致不同的肺癌表现。
在诊断时，肺癌在分期、特定症状或症状数量方面的特征似乎不存在性别差异。
