从发现到验证对癌症患者疗效的科学之旅：哈姆雷特蛋白与α-1-油酸酯
A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate.
作者信息
Ho James C S, Ambite Ines, Mok K H, Babjuk Marek, Svanborg Catharina
机构信息
Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University, Lund, Sweden.
Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore.
出版信息
Mol Cell Oncol. 2021 Sep 30;8(5):1974278. doi: 10.1080/23723556.2021.1974278. eCollection 2021.
The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are presented.
源自HAMLET（人α-乳白蛋白使肿瘤细胞致死）的蛋白质-脂质复合物α1-油酸酯，被确定为一种具有重大治疗潜力的分子实体。本文介绍了该复合物的结构特征以及一项成功的安慰剂对照临床试验的结果。
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