Gondi Vinai, Meyer Jacquelyn, Shih Helen A
Northwestern Medicine Cancer Center Warrenville and Proton Center, Warrenville, Illinois, USA.
University of Wisconsin-Madison, Madison, Wisconsin, USA.
Neurooncol Adv. 2021 Nov 27;3(Suppl 5):v26-v34. doi: 10.1093/noajnl/vdab126. eCollection 2021 Nov.
As novel systemic therapies yield improved survival in metastatic cancer patients, the frequency of brain metastases continues to increase. Over the years, management strategies have continued to evolve. Historically, stereotactic radiosurgery has been used as a boost to whole-brain radiotherapy (WBRT) but is increasingly being used as a replacement for WBRT. Given its capacity to treat both macro- and micro-metastases in the brain, WBRT has been an important management strategy for years, and recent research has identified technologic and pharmacologic approaches to delivering WBRT more safely. In this review, we outline the current landscape of radiotherapeutic treatment options and discuss approaches to integrating radiotherapy advances in the contemporary management of brain metastases.
随着新型全身治疗方法提高了转移性癌症患者的生存率，脑转移瘤的发生率持续上升。多年来，治疗策略不断发展。从历史上看，立体定向放射外科一直被用作全脑放疗（WBRT）的补充，但现在越来越多地被用作WBRT的替代方法。鉴于其能够治疗脑内的宏观和微观转移瘤，WBRT多年来一直是一种重要的治疗策略，最近的研究已经确定了更安全地进行WBRT的技术和药物方法。在这篇综述中，我们概述了放射治疗选择的当前格局，并讨论了在当代脑转移瘤管理中整合放疗进展的方法。
