Institute of Reproductive Health and Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Cell Mol Med. 2022 Jan;26(1):16-24. doi: 10.1111/jcmm.17088. Epub 2021 Dec 3.
CDC42 is a member of the Rho-GTPase family and is involved in a variety of cellular functions including regulation of cell cycle progression, constitution of the actin backbone and membrane transport. In particular, CDC42 plays a key role in the establishment of polarity in female vertebrate oocytes, and essential to this major regulatory role is its local occupation of specific regions of the cell to ensure that the contractile ring is assembled at the right time and place to ensure proper gametogenesis. The multifactor controlled 'inactivation-activation' process of CDC42 also allows it to play an important role in the multilevel signalling network, and the synergistic regulation of multiple genes ensures maximum precision during gametogenesis. The purpose of this paper is to review the role of CDC42 in the control of gametogenesis and to explore its related mechanisms, with the aim of further understanding the great research potential of CDC42 in female vertebrate germ cells and its future clinical translation.
CDC42 是 Rho-GTPase 家族的成员，参与多种细胞功能，包括细胞周期进程的调节、肌动蛋白骨架的构成和膜转运。特别是，CDC42 在雌性脊椎动物卵母细胞极性的建立中起着关键作用，对于这个主要的调节作用，其在细胞的特定区域的局部占据是必不可少的，以确保收缩环在正确的时间和地点组装，以确保正常的配子发生。CDC42 的多因素控制的“失活-激活”过程也使其能够在多层次信号网络中发挥重要作用，并且多个基因的协同调节确保了配子发生过程中的最大精度。本文旨在综述 CDC42 在配子发生控制中的作用及其相关机制，以期进一步了解 CDC42 在雌性脊椎动物生殖细胞中的巨大研究潜力及其未来的临床转化。
