牛津生物银行中体脂分布与骨密度的相关性：一项横断面研究。
The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study.
机构信息
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.
NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford, UK.
出版信息
Expert Rev Endocrinol Metab. 2022 Jan;17(1):75-81. doi: 10.1080/17446651.2022.2008238. Epub 2021 Dec 3.
BACKGROUND
Body composition is associated with bone mineral density (BMD), but the precise associations between body fat distribution and BMD remain unclear. The regional adipose tissue depots have different metabolic profiles. We hypothesized that they would have independent associations with BMD.
RESEARCH DESIGN AND METHODS
We used data from 4,900 healthy individuals aged 30-50 years old from the Oxford Biobank to analyze associations between regional fat mass, lean mass and total BMD.
RESULTS
Total lean mass was strongly positively associated with BMD. An increase in total BMD was observed with increasing mass of all the fat depots, as measured either by anthropometry or DXA, when accounting for lean mass. However, on adjustment for both total fat mass and lean mass, fat depot specific associations emerged. Increased android and visceral adipose tissue mass in men, and increased visceral adipose tissue mass in women, were associated with lower BMD.
CONCLUSIONS
Fat distribution alters the association between adiposity and BMD.
背景
体成分与骨密度（BMD）相关，但身体脂肪分布与 BMD 的确切关联尚不清楚。局部脂肪组织具有不同的代谢特征。我们假设它们与 BMD 有独立的关联。
研究设计和方法
我们使用牛津生物银行中 4900 名年龄在 30-50 岁的健康个体的数据，分析了局部脂肪量、瘦体重与总 BMD 之间的关系。
结果
总瘦体重与 BMD 呈强烈正相关。在考虑瘦体重的情况下，通过人体测量或 DXA 测量，所有脂肪沉积的质量增加，均观察到总 BMD 增加。然而，在调整总脂肪量和瘦体重后，出现了脂肪沉积特异性关联。男性的腹型和内脏脂肪组织质量增加，女性的内脏脂肪组织质量增加，与较低的 BMD 相关。
结论
脂肪分布改变了肥胖与 BMD 之间的关联。
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