Russo Irene, Fagotto Laura, Colombo Anna, Sartor Emma, Luisetto Roberto, Alaibac Mauro
Unit of Dermatology, University of Padua, Padova, Italy.
DISCOG-Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Expert Opin Biol Ther. 2022 Apr;22(4):509-517. doi: 10.1080/14712598.2022.2012147. Epub 2021 Dec 3.
Near-Infrared Photoimmunotherapy (NIR-PIT) is a novel molecularly targeted phototherapy. This technique is based on a conjugate of a near-infrared photo-inducible molecule (antibody-photon absorber conjugate, APC) and a monoclonal antibody that targets a tumor-specific antigen. To date, this novel approach has been successfully applied to several types of cancer.
The authors discuss the possible use of NIR-PIT for the management of skin diseases, with special attention given to squamous cell carcinomas, advanced melanomas, and primary cutaneous lymphomas.
NIR-PIT may be an attractive strategy for the treatment of skin disorders. The main advantage of NIR-PIT therapy is its low toxicity to healthy tissues. Cutaneous lymphocyte antigen is a potential molecular target for NIR-PIT for both cutaneous T-cell lymphomas and inflammatory skin disorders.
近红外光免疫疗法（NIR-PIT）是一种新型的分子靶向光疗法。该技术基于近红外光诱导分子（抗体-光子吸收剂偶联物，APC）与靶向肿瘤特异性抗原的单克隆抗体的偶联物。迄今为止，这种新方法已成功应用于多种类型的癌症。
作者讨论了NIR-PIT在皮肤病治疗中的可能应用，特别关注鳞状细胞癌、晚期黑色素瘤和原发性皮肤淋巴瘤。
NIR-PIT可能是治疗皮肤疾病的一种有吸引力的策略。NIR-PIT疗法的主要优点是对健康组织毒性低。皮肤淋巴细胞抗原是NIR-PIT治疗皮肤T细胞淋巴瘤和炎症性皮肤病的潜在分子靶点。
