用于治疗皮肤疾病的近红外光免疫疗法。
Near-infrared photoimmunotherapy for the treatment of skin disorders.
作者信息
Russo Irene, Fagotto Laura, Colombo Anna, Sartor Emma, Luisetto Roberto, Alaibac Mauro
机构信息
Unit of Dermatology, University of Padua, Padova, Italy.
DISCOG-Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
出版信息
Expert Opin Biol Ther. 2022 Apr;22(4):509-517. doi: 10.1080/14712598.2022.2012147. Epub 2021 Dec 3.
INTRODUCTION
Near-Infrared Photoimmunotherapy (NIR-PIT) is a novel molecularly targeted phototherapy. This technique is based on a conjugate of a near-infrared photo-inducible molecule (antibody-photon absorber conjugate, APC) and a monoclonal antibody that targets a tumor-specific antigen. To date, this novel approach has been successfully applied to several types of cancer.
AREAS COVERED
The authors discuss the possible use of NIR-PIT for the management of skin diseases, with special attention given to squamous cell carcinomas, advanced melanomas, and primary cutaneous lymphomas.
EXPERT OPINION
NIR-PIT may be an attractive strategy for the treatment of skin disorders. The main advantage of NIR-PIT therapy is its low toxicity to healthy tissues. Cutaneous lymphocyte antigen is a potential molecular target for NIR-PIT for both cutaneous T-cell lymphomas and inflammatory skin disorders.
引言
近红外光免疫疗法（NIR-PIT）是一种新型的分子靶向光疗法。该技术基于近红外光诱导分子（抗体-光子吸收剂偶联物，APC）与靶向肿瘤特异性抗原的单克隆抗体的偶联物。迄今为止，这种新方法已成功应用于多种类型的癌症。
涵盖领域
作者讨论了NIR-PIT在皮肤病治疗中的可能应用，特别关注鳞状细胞癌、晚期黑色素瘤和原发性皮肤淋巴瘤。
专家观点
NIR-PIT可能是治疗皮肤疾病的一种有吸引力的策略。NIR-PIT疗法的主要优点是对健康组织毒性低。皮肤淋巴细胞抗原是NIR-PIT治疗皮肤T细胞淋巴瘤和炎症性皮肤病的潜在分子靶点。
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