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血清糖蛋白与头颈部癌症的预后

Serum glycoproteins and prognosis in cancer of the head and neck.

作者信息

Suarez Nieto C, Cuesta Garcia A, Fernandez Bustillo E, Mendez Colunga J C, Alvarez Marcos C

出版信息

Clin Otolaryngol Allied Sci. 1986 Feb;11(1):41-5. doi: 10.1111/j.1365-2273.1986.tb00105.x.

DOI:10.1111/j.1365-2273.1986.tb00105.x
PMID:3486058
Abstract

Alpha 1 acid glycoprotein, alpha 1 antitrypsin, haptoglobin, alpha 2 HS glycoprotein and prealbumin were studied in 44 patients with cancer of the head and neck and in a control group. The three primary glycoproteins were considerably elevated in the patients, particularly in stage IV. In the group of patients who died before 30 months after treatment the haptoglobin was significantly elevated compared to those who survived beyond this point. Only values for the alpha 1 acid glycoprotein greater than 150 mg/dl were a prognostic factor of similar precision to that of stage IV. This correlation could not be shown for the other glycoproteins.

摘要

对44例头颈癌患者及一个对照组的α1酸性糖蛋白、α1抗胰蛋白酶、触珠蛋白、α2HS糖蛋白和前白蛋白进行了研究。三种主要糖蛋白在患者中显著升高,尤其是在IV期。在治疗后30个月内死亡的患者组中,触珠蛋白相比于存活超过此时间点的患者显著升高。仅α1酸性糖蛋白大于150mg/dl的值是与IV期具有相似精度的预后因素。其他糖蛋白未显示出这种相关性。

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引用本文的文献

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O Labeling for a Quantitative Proteomic Analysis of Glycoproteins in Hepatocellular Carcinoma.肝细胞癌中糖蛋白定量蛋白质组分析的标签
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Association of a alpha1 acidic glycoprotein and squamous cell carcinoma of the head and neck.
α1酸性糖蛋白与头颈部鳞状细胞癌的关联。
Pathol Oncol Res. 2001;7(2):111-7. doi: 10.1007/BF03032576.