Bathi R J, Nandimath K, Kannan N, Shetty P
Departments of Oral Medicine & Radiology and Biochemistry, S.D.M. College of Dental Sciences, Dharwad, India.
Indian J Dent Res. 2001 Apr-Jun;12(2):93-9.
Although several serum glycoprotein assays have been conducted for identifying tumor markers and prognosticators of malignancies, presently assessment of effectiveness of treatment of these malignancies remains subjective and good and effective tumor markers and prognosticators of head and neck malignancies are yet to be identified. In our study, serum samples from forty patients with head and neck cancers who were divided into four groups of ten patients each on the basis of their clinical staging and serum samples from ten healthy individuals comprising the control group was taken and subjected to biochemical analysis of serum protein bound hexose, serum fucose, serum sialic acid levels before starting treatment of the cancers and after completion of the cancer treatment and compared with the levels of these serum glycoproteins amongst the control group. All the head and neck cancer patients showed elevated levels of the serum glycoproteins as compared to the control group. It was further noted that the increased levels of the serum glycoproteins correlated well with the clinical staging of the malignancies. Post-treatment levels of all the serum glycoproteins were decreased significantly but, only the serum sialic acid level in 6 out of 10 patients with stage-I malignancy returned to the base line levels as seen in the control group. Serum sialic acid levels showed very close correlation with tumor staging and maybe considered as a good tumor marker and prognosticator for detection of cancer and evaluation of effectiveness of treatment of head and neck malignancies.
尽管已经进行了多种血清糖蛋白检测以识别肿瘤标志物和恶性肿瘤的预后指标，但目前对这些恶性肿瘤治疗效果的评估仍然主观，并且尚未确定头颈恶性肿瘤的良好有效肿瘤标志物和预后指标。在我们的研究中，采集了40名头颈癌患者的血清样本，根据临床分期将他们分为四组，每组10名患者，同时采集了10名健康个体（作为对照组）的血清样本，并在癌症治疗开始前和癌症治疗完成后对血清蛋白结合己糖、血清岩藻糖、血清唾液酸水平进行生化分析，并与对照组中这些血清糖蛋白的水平进行比较。与对照组相比，所有头颈癌患者的血清糖蛋白水平均升高。进一步指出，血清糖蛋白水平的升高与恶性肿瘤的临床分期密切相关。所有血清糖蛋白的治疗后水平均显著降低，但在10名I期恶性肿瘤患者中，只有6名患者的血清唾液酸水平恢复到对照组的基线水平。血清唾液酸水平与肿瘤分期显示出非常密切的相关性，可能被视为检测癌症和评估头颈恶性肿瘤治疗效果的良好肿瘤标志物和预后指标。
