人类补体第四成分（C4）两种形式的生物学特性差异。
Difference in the biological properties of the two forms of the fourth component of human complement (C4).
作者信息
Schifferli J A, Steiger G, Paccaud J P, Sjöholm A G, Hauptmann G
出版信息
Clin Exp Immunol. 1986 Feb;63(2):473-7.
Abstract
The two forms of human C4 were compared in their haemolytic activity and in their capacity to mediate inhibition of immune complex precipitation in human C4 deficient sera. Whereas haemolysis by C4B was 3.2 fold more efficient than by C4A, C4A was 1.7 fold more efficient at inhibiting immune precipitation than C4B. Thus the biological properties of the two forms of human C4 are different and it is suggested that C4A is mainly involved in immune complex clearance reactions.
摘要
对人C4的两种形式进行了溶血活性以及介导人C4缺陷血清中免疫复合物沉淀抑制的能力方面的比较。C4B介导的溶血效率比C4A高3.2倍，而C4A在抑制免疫沉淀方面比C4B高效1.7倍。因此，人C4的两种形式的生物学特性不同，提示C4A主要参与免疫复合物清除反应。
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