Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine.
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang.
Eur J Cancer Prev. 2022 Sep 1;31(5):408-414. doi: 10.1097/CEJ.0000000000000724. Epub 2021 Dec 2.
The risk of gastric cancer based on a family history of gastric cancer remains unclear. The purpose of this study was to investigate the relationship between gastric cancer and family history of gastric cancer within a large cohort in Korea.
In total 211 708 participants were recruited in the Korean Genome and Epidemiology Study during 2001-2013, and divided into a group with a self-reported personal history of gastric cancer ( n = 930) and a 1:40 matched control group ( n = 37 200). We examined the family history of gastric cancer in first-degree relatives for cross-sectional analysis. Logistic regression was used to estimate the odds ratios (ORs) of gastric cancer according to family history, using four models that were adjusted for different confounding variables, including the interaction among a family history of gastric cancer.
After matching the two groups for age and sex, the gastric cancer group had a significantly higher proportion of family history in each relative than the controls ( P < 0.001). In the adjusted model, the ORs [95% confidence interval (CI)] for gastric cancer with a history of an affected father, mother and sibling were 1.80 (1.38-2.34), 1.95 (1.42-2.69) and 2.98 (2.31-3.83), respectively, compared with those in the control group. There was no statistically significant interaction among a family history of gastric cancer in each relative.
A history of gastric cancer in siblings, among first-degree relatives, is strongly associated with an increased risk of gastric cancer. Regular follow-up and early treatment are recommended for those with a family history of gastric cancer.
基于胃癌家族史的胃癌风险仍不清楚。本研究旨在调查韩国大样本队列中胃癌与胃癌家族史之间的关系。
2001-2013 年间，共有 211708 名参与者参加了韩国基因组和流行病学研究，将其分为有自我报告的胃癌个人史组（n=930）和按 1:40 匹配的对照组（n=37200）。我们对一级亲属的胃癌家族史进行了横断面分析。使用调整了不同混杂变量（包括胃癌家族史之间的相互作用）的四个模型，通过逻辑回归估计了胃癌的比值比（ORs），以家族史为依据。
在匹配两组年龄和性别后，胃癌组每个亲属的家族史比例均显著高于对照组（P<0.001）。在调整模型中，有胃癌家族史的父亲、母亲和兄弟姐妹患胃癌的 ORs（95%置信区间[CI]）分别为 1.80（1.38-2.34）、1.95（1.42-2.69）和 2.98（2.31-3.83），与对照组相比。每个一级亲属的胃癌家族史之间没有统计学显著的相互作用。
一级亲属中兄弟姐妹的胃癌史与胃癌风险的增加密切相关。对于有胃癌家族史的人，建议进行定期随访和早期治疗。
