Clauvel J P, Tchobroutsky C, Danon F, Sultan Y, Intrator L, Brouet J C
Clin Immunol Immunopathol. 1986 Jun;39(3):523-30. doi: 10.1016/0090-1229(86)90179-0.
Case records of 14 women with spontaneous recurrent fetal wastage were analyzed. Venous and/or arterial thrombosis developed in nine patients and vasospastic symptoms in eight. Every patient had some kind of autoantibodies: prothrombin activation inhibitor was present in seven cases, anticardiolipin in five, and, antimitochondrial antibodies in two. Antinuclear antibodies were present in seven cases, and significant titer of antibodies to single-stranded DNA in nine cases. With a mean follow up of 6.5 years no patient developed systemic lupus erythematosus. It is suggested that such women have a peculiar form of vasculitis.
对14例自然复发性流产妇女的病例记录进行了分析。9例患者出现静脉和/或动脉血栓形成，8例出现血管痉挛症状。每位患者都有某种自身抗体：7例存在凝血酶原激活抑制剂，5例存在抗心磷脂抗体，2例存在抗线粒体抗体。7例存在抗核抗体，9例存在高滴度的单链DNA抗体。平均随访6.5年，无患者发生系统性红斑狼疮。提示此类女性患有特殊形式的血管炎。
