Pattison N S, McKay E J, Liggins G C, Lubbe W F
N Z Med J. 1987 Feb 11;100(817):61-4.
A solid phase ELISA was developed to investigate the association between anticardiolipin antibodies and lupus anticoagulant in pregnancy. Twenty-seven pregnant women with a history of recurrent fetal losses or systemic lupus erythematosus (SLE) were tested for the presence of lupus anticoagulant, anticardiolipin antibodies, antinuclear antibodies (ANA) and anti-single-stranded DNA antibodies. Nineteen women with a total of 49 previous unsuccessful pregnancies were found to have lupus anticoagulant and anticardiolipin antibodies. Three women who had suffered four fetal deaths from six pregnancies had anticardiolipin antibodies without lupus anticoagulant. Cardiolipin antibodies were not detected in the remaining five patients. This assay for measuring anticardiolipin antibodies appears to provide a simple and inexpensive method of identifying women at risk of fetal death from the adverse effects of lupus anticoagulant.
为研究妊娠期间抗心磷脂抗体与狼疮抗凝物之间的关联，开发了一种固相酶联免疫吸附测定法（ELISA）。对27名有反复流产史或系统性红斑狼疮（SLE）病史的孕妇进行了狼疮抗凝物、抗心磷脂抗体、抗核抗体（ANA）和抗单链DNA抗体检测。19名有49次既往妊娠失败史的女性被发现同时存在狼疮抗凝物和抗心磷脂抗体。6次妊娠中有4次胎儿死亡的3名女性有抗心磷脂抗体但无狼疮抗凝物。其余5名患者未检测到心磷脂抗体。这种检测抗心磷脂抗体的方法似乎提供了一种简单且廉价的方法，用于识别因狼疮抗凝物的不良反应而有胎儿死亡风险的女性。
